Metal-catalysed C–H bond activation and borylation

R Bisht, C Haldar, MMM Hassan, ME Hoque… - Chemical Society …, 2022 - pubs.rsc.org
Transition metal-catalysed direct borylation of hydrocarbons via C–H bond activation has
received a remarkable level of attention as a popular reaction in the synthesis of …

Transition metal catalysis controlled by hydrogen bonding in the second coordination sphere

JNH Reek, B de Bruin, S Pullen, TJ Mooibroek… - Chemical …, 2022 - ACS Publications
Transition metal catalysis is of utmost importance for the development of sustainable
processes in academia and industry. The activity and selectivity of metal complexes are …

Strategic evolution in transition metal-catalyzed directed C–H bond activation and future directions

S Rej, A Das, N Chatani - Coordination Chemistry Reviews, 2021 - Elsevier
In the field of C–H bond functionalization chemistry, directed C–H bond activation strategies
are highly appreciated due to the high efficiency and selectivity of such reactions towards a …

Transition metal–catalyzed remote C─ H borylation: An emerging synthetic tool

MMM Hassan, S Guria, S Dey, J Das… - Science …, 2023 - science.org
Transition metal–catalyzed C─ H bond activation and borylation is a powerful synthetic
method that offers versatile synthetic transformation from organoboron compounds to …

Arene diversification through distal C(sp2)−H functionalization

U Dutta, S Maiti, T Bhattacharya, D Maiti - Science, 2021 - science.org
BACKGROUND Organic synthetic chemistry has facilitated the production of medicines,
agrochemicals, food, polymers, dyes, and more through step-and atom-economical …

Synthesis of planar chiral ferrocenes via enantioselective remote C–H activation

L Zhou, HG Cheng, L Li, K Wu, J Hou, C Jiao… - Nature Chemistry, 2023 - nature.com
Planar chiral ferrocenes are widely studied structures in asymmetric catalysis, materials
science and medicinal chemistry. Although synthetic methods for 1, 2-disubstituted planar …

Remote steric control for undirected meta-selective C–H activation of arenes

B Ramadoss, Y Jin, S Asako, L Ilies - Science, 2022 - science.org
Regioselective functionalization of arenes remains a challenging problem in organic
synthesis. Steric interactions are often used to block sites adjacent to a given substituent, but …

Strategies that utilize ion pairing interactions to exert selectivity control in the functionalization of C–H bonds

JE Gillespie, A Fanourakis… - Journal of the American …, 2022 - ACS Publications
Electrostatic attraction between two groups of opposite charge, typically known as ion-
pairing, offers unique opportunities for the design of systems to enable selectivity control in …

Enabling late-stage drug diversification by high-throughput experimentation with geometric deep learning

DF Nippa, K Atz, R Hohler, AT Müller, A Marx… - Nature Chemistry, 2024 - nature.com
Late-stage functionalization is an economical approach to optimize the properties of drug
candidates. However, the chemical complexity of drug molecules often makes late-stage …

Chiral transient directing groups in transition-metal-catalyzed enantioselective C–H bond functionalization

MI Lapuh, S Mazeh, T Besset - ACS Catalysis, 2020 - ACS Publications
Transition-metal-catalyzed C–H bond functionalization has known a rapid evolution in the
last years, offering modern strategies for reaching high molecular complexity in a step-and …