Insights into the properties, biological functions, and regulation of USP21
T An, Y Lu, X Yan, J Hou - Frontiers in Pharmacology, 2022 - frontiersin.org
Deubiquitylating enzymes (DUBs) antagonize ubiquitination by removing ubiquitin from their
substrates. The role of DUBs in controlling various physiological and pathological processes …
substrates. The role of DUBs in controlling various physiological and pathological processes …
[HTML][HTML] Chemical biology tools to study deubiquitinases and Ubl proteases
M Gorka, HM Magnussen, Y Kulathu - Seminars in Cell & Developmental …, 2022 - Elsevier
The reversible attachment of ubiquitin (Ub) and ubiquitin like modifiers (Ubls) to proteins are
crucial post-translational modifications (PTMs) for many cellular processes. Not only do cells …
crucial post-translational modifications (PTMs) for many cellular processes. Not only do cells …
The deubiquitinating enzyme STAMBP is a newly discovered driver of triple-negative breast cancer progression that maintains RAI14 protein stability
Q Yang, D Yan, C Zou, Q Xue, S Lin, Q Huang… - … & Molecular Medicine, 2022 - nature.com
Triple-negative breast cancer (TNBC) is a heterogeneous malignancy in women. It is
associated with poor prognosis, aggressive malignant behavior, and limited treatment …
associated with poor prognosis, aggressive malignant behavior, and limited treatment …
Helicobacter pylori-induced reactive oxygen species direct turnover of CSN-associated STAMBPL1 and augment apoptotic cell death
S Chaithongyot, M Naumann - Cellular and Molecular Life Sciences, 2022 - Springer
Deubiquitinylases (DUBs) are central regulators of the ubiquitin system involved in protein
regulation and cell signalling and are important for a variety of physiological processes …
regulation and cell signalling and are important for a variety of physiological processes …
Ubiquitin Engineering for Interrogating the Ubiquitin–Proteasome System and Novel Therapeutic Strategies
JQ Tang, MM Marchand, G Veggiani - Cells, 2023 - mdpi.com
Protein turnover, a highly regulated process governed by the ubiquitin–proteasome system
(UPS), is essential for maintaining cellular homeostasis. Dysregulation of the UPS has been …
(UPS), is essential for maintaining cellular homeostasis. Dysregulation of the UPS has been …
On the study of deubiquitinases: Using the right tools for the job
Deubiquitinases (DUBs) have been the subject of intense scrutiny in recent years. Many of
their diverse enzymatic mechanisms are well characterized in vitro; however, our …
their diverse enzymatic mechanisms are well characterized in vitro; however, our …
[HTML][HTML] STAMBPL1 promotes the progression of lung adenocarcinoma by inhibiting DHRS2 expression
X Yang, L Ling, C Li, T Hu, C Zhou, J Chen… - Translational …, 2023 - Elsevier
Background Lung cancer is responsible for the majority of cancer deaths in the world. We
found a significant increase of STAMBPL1 expression in lung adenocarcinoma (LUAD) …
found a significant increase of STAMBPL1 expression in lung adenocarcinoma (LUAD) …
Development of an OTUD1 ubiquitin variant inhibitor
OTUD1 (O varian tu mor domain-containing d eubiquitinase 1) is a member of the OTU
domain-containing deubiquitinase family of enzymes involved in immunoregulation and …
domain-containing deubiquitinase family of enzymes involved in immunoregulation and …
SPRED2 promotes autophagy and attenuates inflammatory response in IL-1β induced osteoarthritis chondrocytes via regulating the p38 MAPK signaling pathway
J Wei, G You, H Cheng, C Gao - Tissue and Cell, 2023 - Elsevier
Osteoarthritis (OA) is an age-related degenerative disease primarily characterized by
articular cartilage degeneration. Many inflammatory mediators are upregulated in OA …
articular cartilage degeneration. Many inflammatory mediators are upregulated in OA …
STAMBP is Required for Long-Term Maintenance of Neural Progenitor Cells Derived from hESCs
J Zhang, Y Zhang, Y Liu, T Zhou, G Pan, J He… - Stem Cell Reviews and …, 2024 - Springer
Mutations in STAMBP have been well-established to cause congenital human microcephaly-
capillary malformation (MIC-CAP) syndrome, a rare genetic disorder characterized by global …
capillary malformation (MIC-CAP) syndrome, a rare genetic disorder characterized by global …