Deubiquitylating enzymes (DUBs) antagonize ubiquitination by removing ubiquitin from their
substrates. The role of DUBs in controlling various physiological and pathological processes …

The reversible attachment of ubiquitin (Ub) and ubiquitin like modifiers (Ubls) to proteins are
crucial post-translational modifications (PTMs) for many cellular processes. Not only do cells …

Triple-negative breast cancer (TNBC) is a heterogeneous malignancy in women. It is
associated with poor prognosis, aggressive malignant behavior, and limited treatment …

Deubiquitinylases (DUBs) are central regulators of the ubiquitin system involved in protein
regulation and cell signalling and are important for a variety of physiological processes …

Protein turnover, a highly regulated process governed by the ubiquitin–proteasome system
(UPS), is essential for maintaining cellular homeostasis. Dysregulation of the UPS has been …

Deubiquitinases (DUBs) have been the subject of intense scrutiny in recent years. Many of
their diverse enzymatic mechanisms are well characterized in vitro; however, our …

Background Lung cancer is responsible for the majority of cancer deaths in the world. We
found a significant increase of STAMBPL1 expression in lung adenocarcinoma (LUAD) …

OTUD1 (O varian tu mor domain-containing d eubiquitinase 1) is a member of the OTU
domain-containing deubiquitinase family of enzymes involved in immunoregulation and …

Osteoarthritis (OA) is an age-related degenerative disease primarily characterized by
articular cartilage degeneration. Many inflammatory mediators are upregulated in OA …

Mutations in STAMBP have been well-established to cause congenital human microcephaly-
capillary malformation (MIC-CAP) syndrome, a rare genetic disorder characterized by global …