Diseases of the central nervous system (CNS) remain a significant health, social and
economic problem around the globe. The development of therapeutic strategies for CNS …

Neurodegenerative diseases are multifactorial, initiated by a series of the causative complex
which develops into a certain clinical picture. The pathogenesis and disease course vary …

Glial fibrillary acidic protein (GFAP), an astrocytic cytoskeletal protein, can be measured in
blood samples, and has been associated with Alzheimer's disease (AD). However, plasma …

Alzheimer's disease (AD) is the most common cause of dementia and there is currently no
cure. Novel approaches to treat AD and curb the rapidly increasing worldwide prevalence …

Gut microbiota in interaction with intestinal host tissues influences many brain functions and
microbial dysbiosis has been linked with brain disorders, such as neuropsychiatric …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that deteriorates
cognitive function. Patients with AD generally exhibit neuroinflammation, elevated beta …

The metabolism of L-tryptophan (TRP) regulates homeostasis, immunity, and neuronal
function. Altered TRP metabolism has been implicated in the pathophysiology of various …

Background Both serotonergic signalling disruption and systemic inflammation have been
associated with the pathogenesis of Alzheimer's disease (AD). The common denominator …

Background Tryptophan (TRP) is an essential amino acid that must be provided in the diet.
The kynurenine pathway (KP) is the main route of TRP catabolism into nicotinamide …

Tryptophan (Tryp) is an essential amino acid and the precursor of several neuroactive
compounds within the central nervous system (CNS). Tryp metabolism, the common …