Neuroinflammation and the kynurenine pathway in CNS disease: molecular mechanisms and therapeutic implications
Diseases of the central nervous system (CNS) remain a significant health, social and
economic problem around the globe. The development of therapeutic strategies for CNS …
economic problem around the globe. The development of therapeutic strategies for CNS …
Searching for peripheral biomarkers in neurodegenerative diseases: the tryptophan-kynurenine metabolic pathway
Neurodegenerative diseases are multifactorial, initiated by a series of the causative complex
which develops into a certain clinical picture. The pathogenesis and disease course vary …
which develops into a certain clinical picture. The pathogenesis and disease course vary …
Plasma glial fibrillary acidic protein is elevated in cognitively normal older adults at risk of Alzheimer's disease
P Chatterjee, S Pedrini, E Stoops, K Goozee… - Translational …, 2021 - nature.com
Glial fibrillary acidic protein (GFAP), an astrocytic cytoskeletal protein, can be measured in
blood samples, and has been associated with Alzheimer's disease (AD). However, plasma …
blood samples, and has been associated with Alzheimer's disease (AD). However, plasma …
[HTML][HTML] Can exercise training teach us how to treat Alzheimer's disease?
AM Huuha, CS Norevik, JBN Moreira… - Ageing research …, 2022 - Elsevier
Alzheimer's disease (AD) is the most common cause of dementia and there is currently no
cure. Novel approaches to treat AD and curb the rapidly increasing worldwide prevalence …
cure. Novel approaches to treat AD and curb the rapidly increasing worldwide prevalence …
Activation of aryl hydrocarbon receptor (AhR) in Alzheimer's disease: Role of tryptophan metabolites generated by gut host-microbiota
A Salminen - Journal of Molecular Medicine, 2023 - Springer
Gut microbiota in interaction with intestinal host tissues influences many brain functions and
microbial dysbiosis has been linked with brain disorders, such as neuropsychiatric …
microbial dysbiosis has been linked with brain disorders, such as neuropsychiatric …
Kynurenine pathway metabolites as biomarkers in Alzheimer's disease
Y Liang, S Xie, Y He, M Xu, X Qiao, Y Zhu… - Disease …, 2022 - Wiley Online Library
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that deteriorates
cognitive function. Patients with AD generally exhibit neuroinflammation, elevated beta …
cognitive function. Patients with AD generally exhibit neuroinflammation, elevated beta …
[HTML][HTML] Tryptophan metabolism in central nervous system diseases: pathophysiology and potential therapeutic strategies
Y Huang, M Zhao, X Chen, R Zhang, A Le… - Aging and …, 2023 - ncbi.nlm.nih.gov
The metabolism of L-tryptophan (TRP) regulates homeostasis, immunity, and neuronal
function. Altered TRP metabolism has been implicated in the pathophysiology of various …
function. Altered TRP metabolism has been implicated in the pathophysiology of various …
Metabolic phenotyping reveals a reduction in the bioavailability of serotonin and kynurenine pathway metabolites in both the urine and serum of individuals living with …
Background Both serotonergic signalling disruption and systemic inflammation have been
associated with the pathogenesis of Alzheimer's disease (AD). The common denominator …
associated with the pathogenesis of Alzheimer's disease (AD). The common denominator …
Dynamic changes in metabolites of the kynurenine pathway in Alzheimer's disease, Parkinson's disease, and Huntington's disease: A systematic Review and meta …
Background Tryptophan (TRP) is an essential amino acid that must be provided in the diet.
The kynurenine pathway (KP) is the main route of TRP catabolism into nicotinamide …
The kynurenine pathway (KP) is the main route of TRP catabolism into nicotinamide …
Sex differences in tryptophan metabolism: A systematic review focused on neuropsychiatric disorders
ML Pais, J Martins, M Castelo-Branco… - International Journal of …, 2023 - mdpi.com
Tryptophan (Tryp) is an essential amino acid and the precursor of several neuroactive
compounds within the central nervous system (CNS). Tryp metabolism, the common …
compounds within the central nervous system (CNS). Tryp metabolism, the common …