Melatonin mitigates mitochondrial meltdown: interactions with SIRT3

RJ Reiter, DX Tan, S Rosales-Corral, A Galano… - International journal of …, 2018 - mdpi.com
Melatonin exhibits extraordinary diversity in terms of its functions and distribution. When
discovered, it was thought to be uniquely of pineal gland origin. Subsequently, melatonin …

SARS-CoV-2 and other coronaviruses negatively influence mitochondrial quality control: beneficial effects of melatonin

S Mehrzadi, MY Karimi, A Fatemi, RJ Reiter… - Pharmacology & …, 2021 - Elsevier
Coronaviruses (CoVs) are a group of single stranded RNA viruses, of which some of them
such as SARS-CoV, MERS-CoV, and SARS-CoV-2 are associated with deadly worldwide …

Ischemic brain injury: New insights on the protective role of melatonin

E Ramos, P Patiño, RJ Reiter, E Gil-Martín… - Free Radical Biology …, 2017 - Elsevier
Stroke represents one of the most common causes of brain's vulnerability for many millions
of people worldwide. The plethora of physiopathological events associated with brain …

Melatonin and ischemic stroke: mechanistic roles and action

SS Andrabi, S Parvez… - … in Pharmacological and …, 2015 - Wiley Online Library
Stroke is one of the most devastating neurological disabilities and brain's vulnerability
towards it proves to be fatal and socio‐economic loss of millions of people worldwide …

[HTML][HTML] Pharmacological treatment of vascular dementia: a molecular mechanism perspective

H Kuang, ZF Zhou, YG Zhu, ZK Wan, MW Yang… - Aging and …, 2021 - ncbi.nlm.nih.gov
Vascular dementia (VaD) is a neurodegenerative disease, with cognitive dysfunction
attributable to cerebrovascular factors. At present, it is the second most frequently occurring …

Melatonin salvages lead‐induced neuro‐cognitive shutdown, anxiety, and depressive‐like symptoms via oxido‐inflammatory and cholinergic mechanisms

NA Omeiza, HA Abdulrahim, AI Alagbonsi… - Brain and …, 2021 - Wiley Online Library
Introduction Lead is the most used nonphysiological neurotoxic heavy metal in the world that
has been indicated to interfere with the cognitive and noncognitive processes via numerous …

Transcriptional regulation of antioxidant enzymes activity and modulation of oxidative stress by melatonin in rats under cerebral ischemia/reperfusion conditions

ED Kryl'skii, TN Popova, OA Safonova, AO Stolyarova… - Neuroscience, 2019 - Elsevier
The article studies the effect of melatonin on the intensity of free radical oxidation, the
functioning of the enzymatic components of the antioxidant system and their transcriptional …

Edaravone attenuates oxidative stress induced by chronic cerebral hypoperfusion injury: role of ERK/Nrf2/HO-1 signaling pathway

D Zhang, Y Xiao, P Lv, Z Teng, Y Dong, Q Qi… - Neurological …, 2018 - Taylor & Francis
Objectives The potential protective effects and mechanisms of edaravone have not been
well elucidated in vascular dementia (VaD) induced by chronic cerebral hypoperfusion …

Capsaicin ameliorates the loosening of mitochondria-associated endoplasmic reticulum membranes and improves cognitive function in rats with chronic cerebral …

M Ouyang, Q Zhang, J Shu, Z Wang, J Fan… - Frontiers in Cellular …, 2022 - frontiersin.org
Based on accumulating evidence, vascular factors contribute to cognitive decline and
dementia. Mitochondrial dysfunction is the core pathophysiological mechanism …

Short-and long-term protective effects of melatonin in a mouse model of sepsis-associated encephalopathy

M Ji, D Xia, L Zhu, X Zhu, X Zhou, J Xia, J Yang - Inflammation, 2018 - Springer
Brain dysfunction is a common complication after sepsis and is an independent risk factor for
a poor prognosis, which is partly attributed to the dysregulated inflammatory response and …