Fragment-based drug discovery is a strategy widely used in both academia and
pharmaceutical companies to generate small-molecule protein inhibitors and drug …

miRNAs, short ribonucleic acid gene regulators, are increasingly popular drug targets.
Traditionally 'undruggable'proteins can be targeted via their miRNA gene regulators …

We describe an intuitive and rapid procedure for analyzing experimental data by nonlinear
least-squares fitting (NLSF) in the most widely used spreadsheet program. Experimental …

Fragment-based drug design (FBDD) has emerged as a mainstream approach for the rapid
and efficient identification of building blocks that can be used to develop high-affinity ligands …

Fragment‐based drug design (FBDD) affords active compounds for biological targets. While
there are numerous reports on FBDD by fragment growing/optimization, fragment linking has …

Protein‐templated fragment ligation is a novel concept to support drug discovery and can
help to improve the efficacy of protein ligands. Protein‐templated fragment ligations are …

Nature has the remarkable ability to realize reactions under physiological conditions that
normally would require high temperature and other forcing conditions. In doing so, often …

Cysteine‐reactive small molecules are used as chemical probes of biological systems and
as medicines. Identifying high‐quality covalent ligands requires comprehensive kinetic …

Target‐directed dynamic combinatorial chemistry has emerged as a useful tool for hit
identification, but has not been widely used, in part due to challenges associated with …

A series of tetra-and pentasubstituted polyfunctional dihydropyrroles 5 and 6 were
synthesized via practical multicomponent reactions (MCRs) for research on their structure …