Fragment linking strategies for structure-based drug design
A Bancet, C Raingeval, T Lomberget… - Journal of Medicinal …, 2020 - ACS Publications
Fragment-based drug discovery is a strategy widely used in both academia and
pharmaceutical companies to generate small-molecule protein inhibitors and drug …
pharmaceutical companies to generate small-molecule protein inhibitors and drug …
Drug target miRNAs: chances and challenges
MF Schmidt - Trends in biotechnology, 2014 - cell.com
miRNAs, short ribonucleic acid gene regulators, are increasingly popular drug targets.
Traditionally 'undruggable'proteins can be targeted via their miRNA gene regulators …
Traditionally 'undruggable'proteins can be targeted via their miRNA gene regulators …
Nonlinear least-squares data fitting in Excel spreadsheets
G Kemmer, S Keller - Nature protocols, 2010 - nature.com
We describe an intuitive and rapid procedure for analyzing experimental data by nonlinear
least-squares fitting (NLSF) in the most widely used spreadsheet program. Experimental …
least-squares fitting (NLSF) in the most widely used spreadsheet program. Experimental …
The ways and means of fragment-based drug design
Fragment-based drug design (FBDD) has emerged as a mainstream approach for the rapid
and efficient identification of building blocks that can be used to develop high-affinity ligands …
and efficient identification of building blocks that can be used to develop high-affinity ligands …
Fragment Linking and Optimization of Inhibitors of the Aspartic Protease Endothiapepsin: Fragment‐Based Drug Design Facilitated by Dynamic Combinatorial …
M Mondal, N Radeva, H Fanlo‐Virgós… - Angewandte Chemie …, 2016 - Wiley Online Library
Fragment‐based drug design (FBDD) affords active compounds for biological targets. While
there are numerous reports on FBDD by fragment growing/optimization, fragment linking has …
there are numerous reports on FBDD by fragment growing/optimization, fragment linking has …
Protein‐Templated Fragment Ligations—From Molecular Recognition to Drug Discovery
M Jaegle, EL Wong, C Tauber… - Angewandte Chemie …, 2017 - Wiley Online Library
Protein‐templated fragment ligation is a novel concept to support drug discovery and can
help to improve the efficacy of protein ligands. Protein‐templated fragment ligations are …
help to improve the efficacy of protein ligands. Protein‐templated fragment ligations are …
Mutual leveraging of proximity effects and click chemistry in chemical biology
Nature has the remarkable ability to realize reactions under physiological conditions that
normally would require high temperature and other forcing conditions. In doing so, often …
normally would require high temperature and other forcing conditions. In doing so, often …
High‐Throughput Kinetic Analysis for Target‐Directed Covalent Ligand Discovery
GB Craven, DP Affron, CE Allen… - Angewandte Chemie …, 2018 - Wiley Online Library
Cysteine‐reactive small molecules are used as chemical probes of biological systems and
as medicines. Identifying high‐quality covalent ligands requires comprehensive kinetic …
as medicines. Identifying high‐quality covalent ligands requires comprehensive kinetic …
In situ inhibitor synthesis and screening by fluorescence polarization: an efficient approach for accelerating drug discovery
Target‐directed dynamic combinatorial chemistry has emerged as a useful tool for hit
identification, but has not been widely used, in part due to challenges associated with …
identification, but has not been widely used, in part due to challenges associated with …
A novel class of small-molecule caspase-3 inhibitors prepared by multicomponent reactions
Q Zhu, L Gao, Z Chen, S Zheng, H Shu, J Li… - European journal of …, 2012 - Elsevier
A series of tetra-and pentasubstituted polyfunctional dihydropyrroles 5 and 6 were
synthesized via practical multicomponent reactions (MCRs) for research on their structure …
synthesized via practical multicomponent reactions (MCRs) for research on their structure …