Squamous cell carcinomas (SCCs) represent the most frequent human solid tumors and are
a major cause of cancer mortality. These highly heterogeneous tumors arise from closely …

This review aims to summarize the current knowledge of molecular pathways and their
clinical relevance in melanoma. Metastatic melanoma was a grim diagnosis, but in recent …

In mammals, the p53 family comprises two additional members, p63 and p73 (hereafter
referred to as TP 53, TP 63, and TP 73, respectively). The usage of two alternative promoters …

p63 and p73, the two other members of the p53 family, were identified almost 15 years ago.
Here, we review their potential use for diagnosis, prognosis and prediction of response to …

Metastatic melanoma is one of the most aggressive tumors, with frequent mutations affecting
components of the MAPK pathway, mainly protein kinase BRAF. Despite promising initial …

Immunohistochemistry (IHC) is an important adjunct in the diagnosis of neoplastic skin
diseases. In addition to the many established IHC markers currently in use, new markers …

Simple Summary TP53 is one of the most important tumor suppressor genes, which has
been found to be mutated in more than half of human cancers and is considered the …

Epithelial to mesenchymal transition (EMT) of tumor cells facilitates their progress to
metastasis. In the tumor microenvironment the inflammatory cytokine 1β (IL-1β) has been …

Dicer participates in heterochromatin formation in fission yeast and plants. However,
whether it has a similar role in mammals remains controversial. Here we showed that the …

Malignant melanoma reveals rapidly increasing incidence and mortality rates worldwide. By
now, BRAF inhibition is the standard therapy for advanced melanoma in patients carrying …