Purinergic signalling, ie, the role of nucleotides as extracellular signalling molecules, was
proposed in 1972. However, this concept was not well accepted until the early 1990's when …

Autism spectrum disorder (ASD) has captured the attention of scientists, clinicians and the
lay public because of its uncertain origins and striking and unexplained clinical …

Increasing evidence points to a central role for immune dysregulation in autism spectrum
disorder (ASD). Several ASD risk genes encode components of the immune system and …

A subset of women who are exposed to infection during pregnancy have an increased risk of
giving birth to a child who will later be diagnosed with a neurodevelopmental or …

Microglia are activated in many neurological diseases and have been suggested to play an
important role in the development of affective disorders including major depression. To …

Suramin is 100 years old and is still being used to treat the first stage of acute human
sleeping sickness, caused by Trypanosoma brucei rhodesiense. Suramin is a …

Background Autism spectrum disorder (ASD) is a neurodevelopmental condition with
hallmark behavioral manifestations including impaired social communication and restricted …

Increasing epidemiological and experimental evidence implicates gestational infections as
one important factor involved in the pathogenesis of several neuropsychiatric disorders …

Background Autism spectrum disorder (ASD) is still diagnosed through behavioral
observation, due to a lack of laboratory biomarkers, which could greatly aid clinicians in …

Maternal immune activation (MIA) via infection during pregnancy is known to increase risk
for autism spectrum disorder (ASD). However, it is unclear how MIA disrupts fetal brain gene …