The highly conserved Notch signalling pathway functions in many different developmental
and homeostatic processes, which raises the question of how this pathway can achieve …

Notch signaling is a conserved system of communication between adjacent cells,
influencing numerous cell fate decisions in the development of multicellular organisms …

The Notch signaling pathway relies on a proteolytic cascade to release its transcriptionally
active intracellular domain, on force to unfold a protective domain and permit proteolysis, on …

Notch signaling is evolutionarily conserved and operates in many cell types and at various
stages during development. Notch signaling must therefore be able to generate appropriate …

Notch signalling links the fate of one cell to that of an immediate neighbour and
consequently controls differentiation, proliferation and apoptotic events in multiple metazoan …

Notch receptor activation initiates cell fate decisions and is distinctive in its reliance on
mechanical force and protein glycosylation. The 2.5-angstrom-resolution crystal structure of …

The Notch signalling pathway is evolutionarily conserved and is crucial for the development
and homeostasis of most tissues. Deregulated Notch signalling leads to various diseases …

Physical systems usually exhibit quantum behavior, such as superpositions and
entanglement, only when they are sufficiently decoupled from a lossy environment …

Notch signaling regulates many aspects of metazoan development and tissue renewal.
Accordingly, the misregulation or loss of Notch signaling underlies a wide range of human …

Gliomas represent approximately 30% of all central nervous system tumors and 80% of
malignant brain tumors. To understand the molecular mechanisms underlying the malignant …