Hereditary hemorrhagic telangiectasia: systemic therapies, guidelines, and an evolving standard of care

H Al-Samkari - Blood, The Journal of the American Society of …, 2021 - ashpublications.org
Hereditary hemorrhagic telangiectasia (HHT) management is evolving because of the
emergence and development of antiangiogenic therapies to eliminate bleeding …

Systemic antiangiogenic therapies for bleeding in hereditary hemorrhagic telangiectasia: a practical, evidence-based guide for clinicians

H Al-Samkari - Seminars in Thrombosis and Hemostasis, 2022 - thieme-connect.com
Management of bleeding in hereditary hemorrhagic telangiectasia (HHT), the second most
common hereditary bleeding disorder in the world, is currently undergoing a paradigm shift …

[HTML][HTML] A precision medicine approach to hereditary hemorrhagic telangiectasia and complex vascular anomalies

H Al‐Samkari, W Eng - Journal of Thrombosis and Haemostasis, 2022 - Elsevier
Vascular anomalies represent a diverse group of disorders classified broadly as
malformations or tumors and include the second most common hereditary bleeding disorder …

Medical Therapeutics for the Treatment of Vascular Anomalies: Part 3

K Ricci - Oral and Maxillofacial Surgery Clinics, 2024 - oralmaxsurgery.theclinics.com
Optimal management of complex vascular anomalies aims to not only treat acute issues,
such as infection or effusion, but also prevent potential future complications and improve …

Hereditary hemorrhagic telangiectasia: genetics, pathophysiology, diagnosis, and management

A Viteri-Noël, A González-García, JL Patier… - Journal of clinical …, 2022 - mdpi.com
Hereditary hemorrhagic telangiectasia is an inherited disease related to an alteration in
angiogenesis, manifesting as cutaneous telangiectasias and epistaxis. As complications, it …

Development and validation of a quality of life measurement scale specific to hereditary hemorrhagic telangiectasia: the QoL-HHT

TTT Le, G Martinent, S Dupuis-Girod, A Parrot… - Orphanet Journal of …, 2022 - Springer
Background Hereditary hemorrhagic telangiectasia (HHT) disease is a rare genetic disorder
with symptoms and complications that can significantly affect patients' daily lives. To date, no …

Evaluation of AAV Capsids and Delivery Approaches for Hereditary Hemorrhagic Telangiectasia Gene Therapy

A Yadav, R Liang, K Press, A Schmidt… - Translational Stroke …, 2024 - Springer
Nosebleeds and intracranial hemorrhage from brain arteriovenous malformations (bAVMs)
are among the most devastating symptoms of patients with hereditary hemorrhagic …

[HTML][HTML] The Role of Thalidomide and Its Analogs in the Treatment of Hereditary Hemorrhagic Telangiectasia: A Systematic Review

MC Ugur, M Baysal, EG Umit - Journal of Clinical Medicine, 2024 - mdpi.com
Background: Hereditary hemorrhagic telangiectasia (HHT) is a disease characterized by
arteriovenous malformations and telangiectases, in which the endothelium and immune …

Health-related quality of life outcome measures in individuals with hereditary hemorrhagic telangiectasia: a scoping review

AJ Gong, T Garg, A Khalil, PC Gowda… - American Journal of …, 2024 - journals.sagepub.com
Background Studies evaluating health-related quality of life (HRQOL) in patients with
hereditary hemorrhagic telangiectasia (HHT) have expanded rapidly in the past decade …

Long-term efficacy assessment of current treatment options for epistaxis in HHT

C Dür, L Anschuetz, S Negoias, OC Bulut… - European Archives of …, 2021 - Springer
Purpose Hereditary hemorrhagic telangiectasia (HHT) is a vascular disorder that presents
with recurrent, intractable epistaxis. The aim of this study was to retrospectively analyze the …