Clinical practice guidelines are defined as ''systematically developed statements to assist
practitioner and patient decisions about appropriate heath care for specific clinical …

AIM Probably, the most important and potentially lethal adverse event of azathioprine (AZA)
and mercaptopurine (MP) is myelosuppression. Our aim was to conduct a review of AZA/MP …

The thiopurine drugs azathioprine and 6‐mercaptopurine (6‐MP) are well‐established in the
treatment of inflammatory bowel disease (IBD). However, there is a wide inter‐and intra …

Autoimmune hepatitis (AIH) fulfills the generally accepted contemporary criteria of an
autoimmune liver disease: the presence of autoantibodies and autoreactive T cells, a female …

This review summarises clinical pharmacological aspects of thiopurines in the treatment of
chronic inflammatory bowel disease (IBD). Current knowledge of pharmacogenetically …

Background Thiopurine‐induced leukopenia is the most common dangerous adverse event
in Asians. NUDT 15 R139C was recently proposed to be a promising biomarker for …

AIM To prospectively evaluate whether a relationship between thiopurine methyltransferase
(TPMT) activity and incidence of adverse effects (especially myelotoxicity) exists, in a long …

Azathioprine, mercaptopurine, methotrexate, ciclosporin and tacrolimus all have their
respective niches in the treatment of inflammatory bowel disease. These immunomodulators …

Background: The evidence for testing thiopurine S-methyltransferase (TPMT) enzymatic
activity or genotype before starting therapy with thiopurine-based drugs is unclear. Purpose …

Background Circulating concentrations of 6-thioguanine nucleotide (6-TGN) and 6-methyl
mercaptopurine (6-MMP) are associated with thiopurine efficacy and may predict toxicity …