Acute flaccid myelitis (AFM) has caused motor paralysis in> 560 children in the United
States since 2014. The temporal association of enterovirus (EV) outbreaks with increases in …

Borrelia burgdorferi, the agent of Lyme disease, is estimated to cause> 400,000 annual
infections in the United States. Serology is the primary laboratory method to support the …

Current serological tests for the emerging tick-borne pathogen Borrelia miyamotoi lack
diagnostic accuracy. To improve serodiagnosis, we investigated a protein array …

Single multiplexed assays could replace the standard 2-tiered (STT) algorithm
recommended for the laboratory diagnosis of Lyme disease if they perform with a specificity …

Flaviviruses such as dengue virus (DENV), Zika virus (ZIKV), and yellow fever virus (YFV)
are spread by mosquitoes and cause human disease and mortality in tropical areas. In …

Oropouche virus (OROV) infection of humans is associated with a debilitating febrile illness
that can progress to meningitis or encephalitis. First isolated from a forest worker in Trinidad …

Human babesiosis is a malaria-like illness caused by protozoan parasites of the genus
Babesia. Babesia microti is responsible for most cases of human babesiosis in the United …

The incidence of tick-borne infections in the United States has risen significantly in the past
decade. Ticks can transmit a variety of pathogens, including bacteria, protozoa, and viruses …

Widely employed diagnostic antibody serology for Lyme disease, known as standard two-
tier testing (STTT), exhibits insufficient sensitivity in early Lyme disease, yielding many …

The spread of tick-borne disease (TBD) is escalating globally, driven by climate change and
socio-economic shifts, underlining the urgency to improve surveillance, diagnostics, and …