Cannabidiol as a potential new type of an antipsychotic. A critical review of the evidence

C Rohleder, JK Müller, B Lange… - Frontiers in …, 2016 - frontiersin.org
There is urgent need for the development of mechanistically different and less side-effect
prone antipsychotic compounds. The endocannabinoid system has been suggested to …

Is cannabidiol during neurodevelopment a promising therapy for schizophrenia and autism spectrum disorders?

CM Loss, L Teodoro, GD Rodrigues… - Frontiers in …, 2021 - frontiersin.org
Schizophrenia and autism spectrum disorders (ASD) are psychiatric neurodevelopmental
disorders that cause high levels of functional disabilities. Also, the currently available …

Improved social interaction, recognition and working memory with cannabidiol treatment in a prenatal infection (poly I: C) rat model

AL Osborne, N Solowij, I Babic, XF Huang… - …, 2017 - nature.com
Neuropsychiatric disorders such as schizophrenia are associated with cognitive impairment,
including learning, memory and attention deficits. Antipsychotic drugs are limited in their …

[HTML][HTML] Cannabidiol exhibits anxiolytic but not antipsychotic property evaluated in the social interaction test

V Almeida, R Levin, FF Peres, ST Niigaki… - Progress in Neuro …, 2013 - Elsevier
Cannabidiol (CBD), a non-psychotomimetic compound of the Cannabis sativa, has been
reported to have central therapeutic actions, such as antipsychotic and anxiolytic effects. We …

Cannabidiol administered during peri-adolescence prevents behavioral abnormalities in an animal model of schizophrenia

FF Peres, MC Diana, R Levin, MA Suiama… - Frontiers in …, 2018 - frontiersin.org
Schizophrenia is considered a debilitating neurodevelopmental psychiatric disorder and its
pharmacotherapy remains problematic without recent major advances. The development of …

Does cannabidiol have a role in the treatment of schizophrenia?

A Gururajan, DT Malone - Schizophrenia research, 2016 - Elsevier
Schizophrenia is a debilitating psychiatric disorder which places a significant emotional and
economic strain on the individual and society-at-large. Unfortunately, currently available …

Effects of psychostimulants and antipsychotics on serum lipids in an animal model for schizophrenia

BSB Correia, JV Nani, R Waladares Ricardo… - Biomedicines, 2021 - mdpi.com
Schizophrenia (SCZ) treatment is essentially limited to the use of typical or atypical
antipsychotic drugs, which suppress the main symptoms of this mental disorder. Metabolic …

Effects of cannabinoid drugs on the deficit of prepulse inhibition of startle in an animal model of schizophrenia: the SHR strain

R Levin, FF Peres, V Almeida, MB Calzavara… - Frontiers in …, 2014 - frontiersin.org
Clinical and neurobiological findings suggest that the cannabinoids and the
endocannabinoid system may be implicated in the pathophysiology and treatment of …

[HTML][HTML] Spontaneously Hypertensive Rats (SHR) present deficits in prepulse inhibition of startle specifically reverted by clozapine

R Levin, MB Calzavara, CM Santos… - Progress in Neuro …, 2011 - Elsevier
Deficits in an operational measure of sensorimotor gating–the prepulse inhibition of startle
(PPI)–are presented in psychiatric disorders such as schizophrenia, bipolar disorder, and …

[HTML][HTML] Spontaneously hypertensive rats manifest deficits in emotional response to 22-kHz and 50-kHz ultrasonic playback

KH Olszyński, R Polowy, AD Wardak… - Progress in Neuro …, 2023 - Elsevier
Many symptoms used routinely for human psychiatric diagnosis cannot be directly observed
in animals which cannot describe their internal states. However, the ultrasonic vocalizations …