Cancer is a devastating disease and is the second leading cause of death worldwide.
Surgery, chemotherapy (CT), and/or radiation therapy (RT) are the treatment of choice for …

An inverse correlation between vegetable consumption and the incidence of cancer has
long been described. This protective effect is stronger when cruciferous vegetables are …

Mustard (Brassica juncea) is a cruciferous vegetable used as a food spice and folk medicine
worldwide. Mustard contains numerous phytochemicals such as: vitamins, minerals, dietary …

Several signaling pathways and basic metabolites are responsible for the control of
metabolism in both normal and cancer cells. As emerging hallmarks of cancer metabolism …

Cancer is one of the leading causes of death worldwide, so pursuing effective and safe
therapeutics for cancer is a key research objective nowadays. Doxorubicin (DOX) is one of …

Indole-3-carbinol (I3C) is a bioactive phytochemical abundant in cruciferous vegetables.
One of its main in vivo metabolites is 3, 3′-diindolylmethane (DIM), formed by the …

Simple Summary The aim of our study was to identify metabolites of bacterial origin that play
role in the pathogenesis of breast cancer. We identified indoxylsulfate, a metabolite of the …

A dual-targeting approach is predicted to yield better cancer therapy outcomes.
Consequently, a series of coumarin-based thiazoles (5a–h, 6, and 7a–e) were designed and …

Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer,
accounting for about 90% of cases. Sorafenib, lenvatinib, and the combination of …

Overexpression of drug efflux transporters is commonly associated with multidrug-resistance
in cancer therapy. Here for the first time, we investigated the ability of diindolylmethane …