The growth hormone secretagogue receptor (GHSR) is a G-protein-coupled receptor
(GPCR) highly expressed in the brain, and also in some peripheral tissues. GHSR activity is …

The supramammillary nucleus (SuM) is a small region in the ventromedial posterior
hypothalamus. The SuM has been relatively understudied with much of the prior focus being …

Reinforcement learning and goal-seeking behavior are thought to be mediated by midbrain
dopamine neurons. However, little is known about neural substrates of curiosity and …

Objective The development of effective anti-obesity therapeutics relies heavily on the ability
to target specific brain homeostatic and hedonic mechanisms controlling body weight. To …

The hippocampus is critical for memory formation. The hypothalamic supramammillary
nucleus (SuM) sends long-range projections to hippocampal area CA2. While the SuM-CA2 …

Ghrelin is a stomach-derived hormone that acts via the growth hormone secretagogue
receptor (GHSR). Recent evidence suggests that some of ghrelin's actions may be mediated …

Objective The orexigenic hormone ghrelin exerts its physiological effects by binding to and
activating the growth hormone secretagogue receptor (GHSR). The recent development of a …

Telencephalic cognitive and emotional circuits/functions are strongly modulated by
subcortical inputs. The main focus of past research on the nature of this modulation has …

Objective The lateral parabrachial nucleus (lPBN) in the brainstem has emerged as a key
area involved in feeding control that is targeted by several circulating anorexigenic …

Ghrelin, a stomach-derived orexigenic hormone, has a well-established role in energy
homeostasis, food reward, and emotionality. Noradrenergic neurons of the locus coeruleus …