There are still no effective treatments to prevent, halt, or reverse Alzheimer's disease, but
research advances over the past three decades could change this gloomy picture. Genetic …

This review is concerned with the role of fibrillization of the amyloid β (Aβ)-peptide in
Alzheimer's disease (AD). The perspective is that of a physical chemist, and one aim is to …

Unlike natural macromolecules (eg, nucleic acids and proteins) possessing precisely
defined molar mass, chain sequence, chirality, and topology, synthetic polymers are typically …

Bioinspired polymeric materials are attracting increasing attention due to significant
advantages over their natural counterparts: the ability to precisely tune their structures over a …

In most general terms, polymers and their supramolecular assemblies have been defining
life on this planet since its conception. Polymers of nucleic acids carry the code of life and …

Polymer sequence programmability is required for the diverse structures and complex
properties that are achieved by native biological polymers, but efforts towards controlling the …

The lack of readily available biomarkers is a significant hindrance toward progressing to
effective therapeutic and preventative strategies for Alzheimer's disease (AD). Blood-based …

The world is getting richer. But wealth brings its own burdens. Prosperous people live longer
and old age carries a high risk of dementia—a condition that is so far neither preventable …

Sequence-controlled polymers are an emerging class of synthetic polymers with a regulated
sequence of monomers. In the past decade, tremendous progress has been made in the …

Cell-lineage–specific transcripts are essential for differentiated tissue function, implicated in
hereditary organ failure, and mediate acquired chronic diseases. However, experimental …