Human brain organogenesis: Toward a cellular understanding of development and disease
The construction of the human nervous system is a distinctly complex although highly
regulated process. Human tissue inaccessibility has impeded a molecular understanding of …
regulated process. Human tissue inaccessibility has impeded a molecular understanding of …
Genetics of human brain development
Brain development in humans is achieved through precise spatiotemporal genetic control,
the mechanisms of which remain largely elusive. Recently, integration of technological …
the mechanisms of which remain largely elusive. Recently, integration of technological …
Generation of human striatal organoids and cortico-striatal assembloids from human pluripotent stem cells
Cortico-striatal projections are critical components of forebrain circuitry that regulate
motivated behaviors. To enable the study of the human cortico-striatal pathway and how its …
motivated behaviors. To enable the study of the human cortico-striatal pathway and how its …
A connectomic study of a petascale fragment of human cerebral cortex
We acquired a rapidly preserved human surgical sample from the temporal lobe of the
cerebral cortex. We stained a 1 mm3 volume with heavy metals, embedded it in resin, cut …
cerebral cortex. We stained a 1 mm3 volume with heavy metals, embedded it in resin, cut …
[HTML][HTML] A cross-disorder dosage sensitivity map of the human genome
Rare copy-number variants (rCNVs) include deletions and duplications that occur
infrequently in the global human population and can confer substantial risk for disease. In …
infrequently in the global human population and can confer substantial risk for disease. In …
Prefrontal–amygdala circuits in social decision-making
An increasing amount of research effort is being directed toward investigating the neural
bases of social cognition from a systems neuroscience perspective. Evidence from multiple …
bases of social cognition from a systems neuroscience perspective. Evidence from multiple …
Prenatal interleukin 6 elevation increases glutamatergic synapse density and disrupts hippocampal connectivity in offspring
F Mirabella, G Desiato, S Mancinelli, G Fossati… - Immunity, 2021 - cell.com
Early prenatal inflammatory conditions are thought to be a risk factor for different
neurodevelopmental disorders. Maternal interleukin-6 (IL-6) elevation during pregnancy …
neurodevelopmental disorders. Maternal interleukin-6 (IL-6) elevation during pregnancy …
A standardized social preference protocol for measuring social deficits in mouse models of autism
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by social
communication deficits and other behavioral abnormalities. The three-chamber social …
communication deficits and other behavioral abnormalities. The three-chamber social …
Sequence diversity analyses of an improved rhesus macaque genome enhance its biomedical utility
INTRODUCTION The rhesus macaque (Macaca mulatta) is one of the most widely used
nonhuman primate (NHP) models for studying human biology and disease. As a …
nonhuman primate (NHP) models for studying human biology and disease. As a …
[HTML][HTML] The neurobiology of social play behaviour: past, present and future
EJM Achterberg, LJMJ Vanderschuren - Neuroscience & Biobehavioral …, 2023 - Elsevier
Social play behaviour is a highly energetic and rewarding activity that is of great importance
for the development of brain and behaviour. Social play is abundant during the juvenile and …
for the development of brain and behaviour. Social play is abundant during the juvenile and …