UTIs are amongst the most frequent bacterial infections. However, the clinical phenotypes of
UTI are heterogeneous and range from rather benign, uncomplicated infections to …

Modern medicine is threatened by the global rise of antibiotic resistance, especially among
Gram-negative bacteria. Metallo-β-lactamase (MBL) enzymes are a particular concern and …

Scope These ESCMID guidelines address the targeted antibiotic treatment of third-
generation cephalosporin-resistant Enterobacterales (3GCephRE) and carbapenem …

Background There is a need for oral antibiotic agents that are effective against multidrug-
resistant gram-negative uropathogens. Tebipenem pivoxil hydrobromide is an orally …

Urinary tract infections (UTIs) caused by antibiotic-resistant Gram-negative bacteria are a
growing concern due to limited treatment options. Knowledge of the common uropathogens …

Background The literature on the epidemiology, mortality and treatment of pandrug-resistant
(PDR) Gram-negative bacteria (GNB) is scarce, scattered and controversial. Objectives To …

The management of carbapenem-resistant infections is often based on polymyxins,
tigecycline, aminoglycosides and their combinations. However, in a recent systematic …

Importance Cefepime/enmetazobactam is a novel β-lactam/β-lactamase inhibitor
combination and a potential empirical therapy for resistant gram-negative infections …

Microbial resistance is a serious threat to human health worldwide. Among the World Health
Organisation's list of priority resistant bacteria, three are listed as critical—the highest level of …

There is a clear need for simple resources to improve the quality of antibiotic prescribing
globally. The AWaRe book was designed as a tool to make the antibiotics section of the …