How COVID-19 shaped mental health: from infection to pandemic effects

BWJH Penninx, ME Benros, RS Klein, CH Vinkers - Nature medicine, 2022 - nature.com
Abstract The Coronavirus Disease 2019 (COVID-19) pandemic has threatened global
mental health, both indirectly via disruptive societal changes and directly via …

Hypoxia signaling in human health and diseases: implications and prospects for therapeutics

Z Luo, M Tian, G Yang, Q Tan, Y Chen, G Li… - Signal transduction and …, 2022 - nature.com
Molecular oxygen (O2) is essential for most biological reactions in mammalian cells. When
the intracellular oxygen content decreases, it is called hypoxia. The process of hypoxia is …

Could SARS-CoV-2 spike protein be responsible for long-COVID syndrome?

TC Theoharides - Molecular Neurobiology, 2022 - Springer
SARS-CoV-2 infects cells via its spike protein binding to its surface receptor on target cells
and results in acute symptoms involving especially the lungs known as COVID-19. However …

Neuroinflammation and COVID-19

A Vanderheiden, RS Klein - Current opinion in neurobiology, 2022 - Elsevier
Abstract Coronavirus disease 2019 (COVID-19) has caused a historic pandemic of
respiratory disease. COVID-19 also causes acute and post-acute neurological symptoms …

[HTML][HTML] 'Spikeopathy': COVID-19 spike protein is pathogenic, from both virus and vaccine mRNA

PI Parry, A Lefringhausen, C Turni, CJ Neil, R Cosford… - Biomedicines, 2023 - mdpi.com
The COVID-19 pandemic caused much illness, many deaths, and profound disruption to
society. The production of 'safe and effective'vaccines was a key public health target. Sadly …

Pericyte loss in diseases

P Li, H Fan - Cells, 2023 - mdpi.com
Pericytes are specialized cells located in close proximity to endothelial cells within the
microvasculature. They play a crucial role in regulating blood flow, stabilizing vessel walls …

Immune response and molecular mechanisms of cardiovascular adverse effects of spike proteins from SARS-CoV-2 and mRNA vaccines

P Bellavite, A Ferraresi, C Isidoro - Biomedicines, 2023 - mdpi.com
The SARS-CoV-2 (severe acute respiratory syndrome coronavirus responsible for the
COVID-19 disease) uses the Spike proteins of its envelope for infecting target cells …

An update on angiotensin-converting enzyme 2 structure/functions, polymorphism, and duplicitous nature in the pathophysiology of coronavirus disease 2019 …

CA Devaux, L Camoin-Jau - Frontiers in microbiology, 2022 - frontiersin.org
It has been known for many years that the angiotensin-converting enzyme 2 (ACE2) is a cell
surface enzyme involved in the regulation of blood pressure. More recently, it was proven …

SARS-CoV-2 and multiple sclerosis: potential for disease exacerbation

M MacDougall, J El-Hajj Sleiman… - Frontiers in …, 2022 - frontiersin.org
While the respiratory tract is the primary route of entry for SARS-CoV-2, evidence shows that
the virus also impacts the central nervous system. Intriguingly, case reports have …

Recombinant SARS-CoV-2 Spike Protein and its Receptor Binding Domain stimulate release of different pro-inflammatory mediators via activation of distinct receptors …

I Tsilioni, TC Theoharides - Molecular Neurobiology, 2023 - Springer
SARS-CoV-2 infects cells via its spike (S) protein binding to its surface receptor angiotensin
converting enzyme 2 (ACE2) on target cells and results in acute symptoms involving …