Alzheimer's disease (AD) has traditionally been regarded as a disease of the gray matter
(GM). However, the advent of diffusion tensor imaging (DTI) has contributed to new …

Structural magnetic resonance imaging (MRI) studies of Alzheimer's disease and mild
cognitive impairment (MCI) have focused on the hippocampus and entorhinal cortex; gray …

Objective: White matter hyperintensities (WMH) are commonly seen on neuroimaging scans,
but their underlying histopathologic substrate is unclear. The aim of this work was to …

Prior work has demonstrated that the memory dysfunction of Alzheimer's disease (AD) is
accompanied by marked cortical pathology in medial temporal lobe (MTL) gray matter. In …

We have investigated alterations in myelin associated with Aβ plaques, a major pathological
hallmark of Alzheimer's disease (AD), in human tissue and relevant transgenic mice models …

BACKGROUND AND PURPOSE: Along with cortical abnormalities, white matter
microstructural changes such as axonal loss and myelin breakdown are implicated in the …

Myelination is a recent evolutionary addition that significantly enhances the speed of
transmission in the neural network. Even slight defects in myelin integrity impair …

Mild cognitive impairment (MCI) as a clinical diagnosis has limited specificity, and identifying
imaging biomarkers may improve its predictive validity as a pre-dementia syndrome. This …

Cerebral white matter lesions (WML) are common in the aging brain and are associated with
dementia and depression. They are associated with vascular risk factors and small vessel …

Although much prior work has focused on the known cortical pathology that defines
Alzheimer's disease (AD) histologically, recent work has additionally demonstrated …