Long-COVID post-viral chronic fatigue and affective symptoms are associated with oxidative damage, lowered antioxidant defenses and inflammation: a proof of …

HK Al-Hakeim, HT Al-Rubaye, DS Al-Hadrawi… - Molecular …, 2023 - nature.com
The immune-inflammatory response during the acute phase of COVID-19, as assessed
using peak body temperature (PBT) and peripheral oxygen saturation (SpO2), predicts the …

Understanding the role of free radicals and antioxidant enzymes in human diseases

Z Roy, R Bansal, L Siddiqui… - Current Pharmaceutical …, 2023 - ingentaconnect.com
Antioxidant enzymes being an integral part of the defense mechanism have a crucial role in
cellular metabolism, essential for healthy growth and living of the cells. The main function is …

Oxidative stress-induced endothelial dysfunction and decreased vascular nitric oxide in COVID-19 patients

V Montiel, I Lobysheva, L Gerard, M Vermeersch… - …, 2022 - thelancet.com
Background SARS-CoV-2 targets endothelial cells through the angiotensin-converting
enzyme 2 receptor. The resulting endothelial injury induces widespread thrombosis and …

Molecular mechanisms related to responses to oxidative stress and antioxidative therapies in COVID-19: A systematic review

EE Tsermpini, U Glamočlija, F Ulucan-Karnak… - Antioxidants, 2022 - mdpi.com
The coronavirus disease (COVID-19) pandemic is a leading global health and economic
challenge. What defines the disease's progression is not entirely understood, but there are …

Hyperglycemia and loss of redox homeostasis in COVID-19 patients

ME Soto, V Guarner-Lans, E Díaz-Díaz… - Cells, 2022 - mdpi.com
The infection with SARS-CoV-2 impairs the glucose–insulin axis and this contributes to
oxidative (OS) and nitrosative (NSS) stress. Here, we evaluated changes in glucose …

Hematological, inflammatory, coagulation, and oxidative/antioxidant biomarkers as predictors for severity and mortality in COVID-19: a prospective cohort-study

SW Smail, E Babaei, K Amin - International Journal of General …, 2023 - Taylor & Francis
Purpose Oxidative stress (OS) and inflammation are pivotal points in the pathophysiology of
coronavirus disease-2019 (COVID-19). This study aims to use routine laboratory and …

Effects of COVID-19 disease on DNA damage, oxidative stress and immune responses

MM Basaran, M Hazar, M Aydın, G Uzuğ, İ Özdoğan… - Toxics, 2023 - mdpi.com
Coronavirus disease 2019 (COVID-19) has posed a great threat to public health and has
caused concern due to its fatal consequences over the last few years. Most people with …

N-Acetyl cysteine restores the diminished activity of the antioxidant enzymatic system caused by SARS-CoV-2 infection: Preliminary findings

ME Soto, L Manzano-Pech, A Palacios-Chavarría… - Pharmaceuticals, 2023 - mdpi.com
SARS-CoV-2 infects type II pneumocytes and disrupts redox homeostasis by overproducing
reactive oxygen species (ROS). N-acetyl cysteine (NAC) is a precursor of the synthesis of …

Do the oxidative stress biomarkers predict COVID-19 outcome? An in-hospital cohort study

FF Neves, H Pott-Junior, KMC Yamashita… - Free Radical Biology …, 2023 - Elsevier
In SARSCoV-2 infections, excessive activation of the immune system dramatically elevates
reactive oxygen species levels, harms cell structures, and directly increases disease severity …

Precision nutrition to reset virus-induced human metabolic reprogramming and dysregulation (HMRD) in long-COVID

AS Naidu, CK Wang, P Rao, F Mancini… - npj Science of …, 2024 - nature.com
Abstract SARS‐CoV‐2, the etiological agent of COVID-19, is devoid of any metabolic
capacity; therefore, it is critical for the viral pathogen to hijack host cellular metabolic …