Advanced glycosylation end products (AGEs) are a series of complex compounds which
generate in the advanced phase of Maillard reaction, which can pose a non-negligible risk …

Metabolism is an essential part of life that provides energy for cell growth. During metabolic
flux, reactive electrophiles are produced that covalently modify macromolecules, leading to …

The tripeptide glutathione (GSH), namely γ-L-glutamyl-L-cysteinyl-glycine, is an ubiquitous
low-molecular weight thiol nucleophile and reductant of utmost importance, representing the …

Aging refers to the gradual physiological changes that occur in an organism after reaching
adulthood, resulting in senescence and a decline in biological functions, ultimately leading …

Our skin is an organ with the largest contact area between the human body and the external
environment. Skin aging is affected directly by both endogenous factors and exogenous …

Ageing retina is prone to ferroptosis due to the iron accumulation and impaired efficiency of
intracellular antioxidant defense system. Ferroptosis acts as a cell death modality that is …

Methylglyoxal (MG), a toxic compound produced as a by-product of several cellular
processes, such as respiration and photosynthesis, is well known for its deleterious effects …

Reactive α-dicarbonyls (α-DCs), such as methylglyoxal (MGO), glyoxal (GO), and 3-
deoxyglucosone (3-DG), are potent precursors in the formation of advanced glycation end …

Aging is a natural, gradual, and inevitable process associated with a series of changes at
the molecular, cellular, and tissue levels that can lead to an increased risk of many diseases …

Advanced glycation end products (AGEs) can be present in food or be endogenously
produced in biological systems. Their formation has been associated with chronic …