PARP inhibitors: clinical relevance, mechanisms of action and tumor resistance

M Rose, JT Burgess, K O'Byrne, DJ Richard… - Frontiers in cell and …, 2020 - frontiersin.org
The Poly (ADP-ribose) polymerase (PARP) family has many essential functions in cellular
processes, including the regulation of transcription, apoptosis and the DNA damage …

The expanding universe of PARP1-mediated molecular and therapeutic mechanisms

D Huang, WL Kraus - Molecular cell, 2022 - cell.com
ADP-ribosylation (ADPRylation) is a post-translational modification of proteins catalyzed by
ADP-ribosyl transferase (ART) enzymes, including nuclear PARPs (eg, PARP1 and PARP2) …

PARP and PARG inhibitors in cancer treatment

D Slade - Genes & development, 2020 - genesdev.cshlp.org
Oxidative and replication stress underlie genomic instability of cancer cells. Amplifying
genomic instability through radiotherapy and chemotherapy has been a powerful but …

Rucaparib maintenance treatment for recurrent ovarian carcinoma after response to platinum therapy (ARIEL3): a randomised, double-blind, placebo-controlled …

RL Coleman, AM Oza, D Lorusso, C Aghajanian… - The Lancet, 2017 - thelancet.com
Background Rucaparib, a poly (ADP-ribose) polymerase inhibitor, has anticancer activity in
recurrent ovarian carcinoma harbouring a BRCA mutation or high percentage of genome …

The multifaceted roles of PARP1 in DNA repair and chromatin remodelling

A Ray Chaudhuri, A Nussenzweig - Nature reviews Molecular cell …, 2017 - nature.com
Cells are exposed to various endogenous and exogenous insults that induce DNA damage,
which, if unrepaired, impairs genome integrity and leads to the development of various …

High speed of fork progression induces DNA replication stress and genomic instability

A Maya-Mendoza, P Moudry, JM Merchut-Maya… - Nature, 2018 - nature.com
Accurate replication of DNA requires stringent regulation to ensure genome integrity. In
human cells, thousands of origins of replication are coordinately activated during S phase …

Inflammation-induced DNA damage, mutations and cancer

J Kay, E Thadhani, L Samson, B Engelward - DNA repair, 2019 - Elsevier
The relationships between inflammation and cancer are varied and complex. An important
connection linking inflammation to cancer development is DNA damage. During …

Replication fork stability confers chemoresistance in BRCA-deficient cells

A Ray Chaudhuri, E Callen, X Ding, E Gogola… - Nature, 2016 - nature.com
Cells deficient in the Brca1 and Brca2 genes have reduced capacity to repair DNA double-
strand breaks by homologous recombination and consequently are hypersensitive to DNA …

Laying a trap to kill cancer cells: PARP inhibitors and their mechanisms of action

Y Pommier, MJ O'Connor, J De Bono - Science translational medicine, 2016 - science.org
Poly (ADP-ribose) polymerase (PARP) inhibitors are the first DNA damage response
targeted agents approved for cancer therapy. Here, we focus on their molecular mechanism …

The comings and goings of PARP-1 in response to DNA damage

JM Pascal - DNA repair, 2018 - Elsevier
Abstract Poly (ADP-ribose) polymerase (PARP) enzymes are broadly involved in the cellular
response to DNA damage. PARP-1 is the chief human PARP enzyme involved in the DNA …