Targeting cell death pathways for cancer therapy: recent developments in necroptosis, pyroptosis, ferroptosis, and cuproptosis research

X Tong, R Tang, M Xiao, J Xu, W Wang… - Journal of hematology & …, 2022 - Springer
Many types of human cells self-destruct to maintain biological homeostasis and defend the
body against pathogenic substances. This process, called regulated cell death (RCD), is …

Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy

W Gao, X Wang, Y Zhou, X Wang, Y Yu - Signal transduction and …, 2022 - nature.com
In recent years, immunotherapy represented by immune checkpoint inhibitors (ICIs) has led
to unprecedented breakthroughs in cancer treatment. However, the fact that many tumors …

Ferroptosis, necroptosis, and pyroptosis in anticancer immunity

R Tang, J Xu, B Zhang, J Liu, C Liang, J Hua… - Journal of hematology & …, 2020 - Springer
In recent years, cancer immunotherapy based on immune checkpoint inhibitors (ICIs) has
achieved considerable success in the clinic. However, ICIs are significantly limited by the …

The role of pyroptosis in cancer: pro-cancer or pro-“host”?

X Xia, X Wang, Z Cheng, W Qin, L Lei, J Jiang… - Cell death & …, 2019 - nature.com
Programmed cell death (PCD) refers to the way in which cells die depending on specific
genes encoding signals or activities. Apoptosis, autophagy, and pyroptosis are all …

Anthocyanins From Clitoria ternatea Flower: Biosynthesis, Extraction, Stability, Antioxidant Activity, and Applications

GC Vidana Gamage, YY Lim, WS Choo - Frontiers in Plant Science, 2021 - frontiersin.org
Clitoria ternatea plant is commonly grown as an ornamental plant and possesses great
medicinal value. Its flower is edible and also known as blue pea or butterfly pea flower. The …

Antioxidant activity and healthy benefits of natural pigments in fruits: A review

W Lu, Y Shi, R Wang, D Su, M Tang, Y Liu… - International journal of …, 2021 - mdpi.com
Natural pigments, including carotenoids, flavonoids and anthocyanidins, determine the
attractive color of fruits. These natural pigments are essential secondary metabolites, which …

Anthocyanins: Promising natural products with diverse pharmacological activities

J Liu, H Zhou, L Song, Z Yang, M Qiu, J Wang, S Shi - Molecules, 2021 - mdpi.com
Anthocyanins are natural products that give color to plants. As natural plant pigments,
anthocyanins also have a series of health-promoting benefits. Many researchers have …

Mechanism and regulation of pyroptosis-mediated in cancer cell death

J Ruan, S Wang, J Wang - Chemico-biological interactions, 2020 - Elsevier
Pyroptosis, a form of programmed cell death, has garnered increasing attention as it relates
to innate immunity and diseases. The discovery of caspase-1/3/4/5/8/11 function in sensing …

Pyroptosis and pyroptosis-inducing cancer drugs

F Yang, SN Bettadapura, MS Smeltzer, H Zhu… - Acta Pharmacologica …, 2022 - nature.com
Pyroptosis, an inflammatory form of lytic cell death, is a type of cell death mediated by the
gasdermin (GSDM) protein family. Upon recognizing exogenous or endogenous signals …

Involvement of inflammasomes in tumor microenvironment and tumor therapies

Z Zhang, X Li, Y Wang, Y Wei, X Wei - Journal of Hematology & Oncology, 2023 - Springer
Inflammasomes are macromolecular platforms formed in response to damage-associated
molecular patterns (DAMPs) and pathogen-associated molecular patterns, whose formation …