Sarcoma treatment in the era of molecular medicine
Sarcomas are heterogeneous and clinically challenging soft tissue and bone cancers.
Although constituting only 1% of all human malignancies, sarcomas represent the second …
Although constituting only 1% of all human malignancies, sarcomas represent the second …
3D bioprinting of tumor models for cancer research
The exact mechanistic understanding of cancer metastasis continues to be unknown,
although it is a major cause of death worldwide. Along with the tumor mass, the tumor …
although it is a major cause of death worldwide. Along with the tumor mass, the tumor …
Triculture model of in vitro BBB and its application to study BBB‐associated chemosensitivity and drug delivery in glioblastoma
Physiologically, brain tumors interact with surrounding vascular and glial cells, and change
their responses to survive in brain tissue‐specific microenvironments. A major difficulty in …
their responses to survive in brain tissue‐specific microenvironments. A major difficulty in …
Mimicking tumor hypoxia and tumor-immune interactions employing three-dimensional in vitro models
The heterogeneous tumor microenvironment (TME) is highly complex and not entirely
understood. These complex configurations lead to the generation of oxygen-deprived …
understood. These complex configurations lead to the generation of oxygen-deprived …
[HTML][HTML] Advances in biofabrication techniques for collagen-based 3D in vitro culture models for breast cancer research
Collagen is the most abundant component of the extracellular matrix (ECM), therefore it
represents an ideal biomaterial for the culture of a variety of cell types. Recently, collagen …
represents an ideal biomaterial for the culture of a variety of cell types. Recently, collagen …
[HTML][HTML] In vitro biomimetic models for glioblastoma-a promising tool for drug response studies
T Stanković, T Ranđelović, M Dragoj, SS Burić… - Drug Resistance …, 2021 - Elsevier
The poor response of glioblastoma to current treatment protocols is a consequence of its
intrinsic drug resistance. Resistance to chemotherapy is primarily associated with …
intrinsic drug resistance. Resistance to chemotherapy is primarily associated with …
An osteosarcoma model by 3D printed polyurethane scaffold and in vitro generated bone extracellular matrix
N Contessi Negrini, C Ricci, F Bongiorni, L Trombi… - Cancers, 2022 - mdpi.com
Simple Summary Development of new therapeutics to treat osteosarcoma is fundamental to
decreasing its current health impact. 3D in vitro models are gaining tremendous momentum …
decreasing its current health impact. 3D in vitro models are gaining tremendous momentum …
The role of cancer stem cells and mechanical forces in ovarian cancer metastasis
Ovarian cancer is an extremely lethal gynecologic disease; with the high-grade serous
subtype predominantly associated with poor survival rates. Lack of early diagnostic …
subtype predominantly associated with poor survival rates. Lack of early diagnostic …
Effects of doxorubicin delivery by nitrogen-doped graphene quantum dots on cancer cell growth: experimental study and mathematical modeling
M Frieler, C Pho, BH Lee, H Dobrovolny, GR Akkaraju… - Nanomaterials, 2021 - mdpi.com
With 18 million new cases diagnosed each year worldwide, cancer strongly impacts both
science and society. Current models of cancer cell growth and therapeutic efficacy in vitro …
science and society. Current models of cancer cell growth and therapeutic efficacy in vitro …
3D immunocompetent organ‐on‐a‐chip models
In recent years, engineering of various human tissues in microphysiologically relevant
platforms, known as organs‐on‐chips (OOCs), are explored to establish in vitro tissue …
platforms, known as organs‐on‐chips (OOCs), are explored to establish in vitro tissue …