Hypertension is the most common chronic disease in the world, yet the precise cause of
elevated blood pressure often cannot be determined. Animal models have been useful for …

The arterial wall is a composite material of elastin, collagen, and extracellular matrix with
acutely modifiable material properties through the action of smooth muscle cells. Therefore …

The placenta is an essential organ that is formed during pregnancy and its proper
development is critical for embryonic survival. While several animal models have been …

Abdominal aortic aneurysm (AAA) is a permanent expansion of the abdominal aorta that has
a high mortality but limited treatment options. Phosphodiesterase (PDE) 4 family members …

Hypertension induces significant aortic remodelling, often adaptive but sometimes not. To
identify immuno-mechanical mechanisms responsible for differential remodelling, we …

Aims Hypertension is the major cause of cardiovascular diseases and global mortality.
Immunoglobulin E (IgE), which plays crucial roles in allergic diseases, has been implicated …

Emerging evidence has demonstrated that (pro) renin receptor (PRR)-mediated activation of
intrarenal renin-angiotensin system (RAS) plays an essential role in renal handling of Na+ …

Background Although estrogen receptor α (ER α) acts primarily as a transcription factor, it
can also elicit membrane‐initiated steroid signaling. Pharmacological tools and transgenic …

Rationale: Hypoxia promotes renal damage and progression of chronic kidney disease
(CKD). The erythrocyte is the only cell type for oxygen (O2) delivery. Sphingosine 1 …

Dipeptidyl peptidase 3 (DPP3) is a zinc-dependent hydrolase involved in degrading
oligopeptides with 4–12 amino acid residues. It has been associated with several …