Application of PLGA as a biodegradable and biocompatible polymer for pulmonary delivery of drugs
Pulmonary administration of biodegradable polymeric formulation is beneficial in the
treatment of various respiratory diseases. For respiratory delivery, the polymer must be non …
treatment of various respiratory diseases. For respiratory delivery, the polymer must be non …
[HTML][HTML] Inhalable nanoparticle-based dry powder formulations for respiratory diseases: Challenges and strategies for translational research
The emergence of novel respiratory infections (eg, COVID-19) and expeditious development
of nanoparticle-based COVID-19 vaccines have recently reignited considerable interest in …
of nanoparticle-based COVID-19 vaccines have recently reignited considerable interest in …
[HTML][HTML] Modulation of engineered nanomaterial interactions with organ barriers for enhanced drug transport
V Lenders, X Koutsoumpou, P Phan… - Chemical Society …, 2023 - pubs.rsc.org
The biomedical use of nanoparticles (NPs) has been the focus of intense research for over a
decade. As most NPs are explored as carriers to alter the biodistribution, pharmacokinetics …
decade. As most NPs are explored as carriers to alter the biodistribution, pharmacokinetics …
Dry powder inhalers of antitubercular drugs
N Nainwal, Y Sharma, V Jakhmola - Tuberculosis, 2022 - Elsevier
Despite advancements in the medical and pharmaceutical fields, tuberculosis remains a
major health problem globally. Patients do not widely accept the conventional approach to …
major health problem globally. Patients do not widely accept the conventional approach to …
Formulation and evaluation of pravastatin sodium-loaded PLGA nanoparticles: in vitro–in vivo studies assessment
SI Elsayed, GNS Girgis… - International Journal of …, 2023 - Taylor & Francis
Purpose Pravastatin sodium (PVS) is a hypolipidemic drug which suffers from extensive first-
pass metabolism and short half-life. Poly (d, l-lactide-co-glycolide)(PLGA) is considered a …
pass metabolism and short half-life. Poly (d, l-lactide-co-glycolide)(PLGA) is considered a …
[HTML][HTML] Nanosized drug delivery systems to fight tuberculosis
T Bourguignon, JA Godinez-Leon, R Gref - Pharmaceutics, 2023 - mdpi.com
Tuberculosis (TB) is currently the second deadliest infectious disease. Existing
antitubercular therapies are long, complex, and have severe side effects that result in low …
antitubercular therapies are long, complex, and have severe side effects that result in low …
The idiosyncratic efficacy of spironolactone-loaded PLGA nanoparticles against murine intestinal schistosomiasis
Background Schistosomiasis is a chronic debilitating parasitic disease accompanied with
severe mortality rates. Although praziquantel (PZQ) acts as the sole drug for the …
severe mortality rates. Although praziquantel (PZQ) acts as the sole drug for the …
Lipid–polymer hybrid nanoparticles loaded with N-acetylcysteine for the modulation of neuroinflammatory biomarkers in human iPSC-derived PSEN2 (N141I) …
A Vargas-Barona, J Bernáldez-Sarabia… - Journal of Materials …, 2024 - pubs.rsc.org
Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by
cognitive impairment associated with the accumulation of beta-amyloid protein (Aβ). Aβ …
cognitive impairment associated with the accumulation of beta-amyloid protein (Aβ). Aβ …
Design of N-acetylcysteine vesicles as a potential chemopreventive tool in lung cancer: Characterization, Tc-99m radiolabeling and in vivo evaluation
M Nasr, IT Ibrahim, KM Attallah - Journal of Drug Delivery Science and …, 2024 - Elsevier
Lung cancer is a type of cancer which is characterized by high incidence and elevated
mortality rate. In an attempt to counteract the carcinogens' load and prevent the development …
mortality rate. In an attempt to counteract the carcinogens' load and prevent the development …
[HTML][HTML] Spray-dried inhalable powder formulations of gentamicin designed for pneumonic plague therapy in a mouse model
M Zhu, D Zhang, L Zhang, L Zhao, L Xu, B Wang… - Pharmaceutics, 2022 - mdpi.com
Infection with Yersinia pestis (Y. pestis) may cause pneumonic plague, which is inevitably
fatal without treatment. Gentamicin (GM), an aminoglycoside antibiotic, is a drug commonly …
fatal without treatment. Gentamicin (GM), an aminoglycoside antibiotic, is a drug commonly …