Application of PLGA as a biodegradable and biocompatible polymer for pulmonary delivery of drugs

R Mahar, A Chakraborty, N Nainwal, R Bahuguna… - AAPS …, 2023 - Springer
Pulmonary administration of biodegradable polymeric formulation is beneficial in the
treatment of various respiratory diseases. For respiratory delivery, the polymer must be non …

[HTML][HTML] Inhalable nanoparticle-based dry powder formulations for respiratory diseases: Challenges and strategies for translational research

HW Chan, S Chow, X Zhang, Y Zhao, HHY Tong… - AAPS …, 2023 - Springer
The emergence of novel respiratory infections (eg, COVID-19) and expeditious development
of nanoparticle-based COVID-19 vaccines have recently reignited considerable interest in …

[HTML][HTML] Modulation of engineered nanomaterial interactions with organ barriers for enhanced drug transport

V Lenders, X Koutsoumpou, P Phan… - Chemical Society …, 2023 - pubs.rsc.org
The biomedical use of nanoparticles (NPs) has been the focus of intense research for over a
decade. As most NPs are explored as carriers to alter the biodistribution, pharmacokinetics …

Dry powder inhalers of antitubercular drugs

N Nainwal, Y Sharma, V Jakhmola - Tuberculosis, 2022 - Elsevier
Despite advancements in the medical and pharmaceutical fields, tuberculosis remains a
major health problem globally. Patients do not widely accept the conventional approach to …

Formulation and evaluation of pravastatin sodium-loaded PLGA nanoparticles: in vitro–in vivo studies assessment

SI Elsayed, GNS Girgis… - International Journal of …, 2023 - Taylor & Francis
Purpose Pravastatin sodium (PVS) is a hypolipidemic drug which suffers from extensive first-
pass metabolism and short half-life. Poly (d, l-lactide-co-glycolide)(PLGA) is considered a …

[HTML][HTML] Nanosized drug delivery systems to fight tuberculosis

T Bourguignon, JA Godinez-Leon, R Gref - Pharmaceutics, 2023 - mdpi.com
Tuberculosis (TB) is currently the second deadliest infectious disease. Existing
antitubercular therapies are long, complex, and have severe side effects that result in low …

The idiosyncratic efficacy of spironolactone-loaded PLGA nanoparticles against murine intestinal schistosomiasis

WE Abd El Hady, GA El-Emam, NE Saleh… - International Journal …, 2023 - Taylor & Francis
Background Schistosomiasis is a chronic debilitating parasitic disease accompanied with
severe mortality rates. Although praziquantel (PZQ) acts as the sole drug for the …

Lipid–polymer hybrid nanoparticles loaded with N-acetylcysteine for the modulation of neuroinflammatory biomarkers in human iPSC-derived PSEN2 (N141I) …

A Vargas-Barona, J Bernáldez-Sarabia… - Journal of Materials …, 2024 - pubs.rsc.org
Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by
cognitive impairment associated with the accumulation of beta-amyloid protein (Aβ). Aβ …

Design of N-acetylcysteine vesicles as a potential chemopreventive tool in lung cancer: Characterization, Tc-99m radiolabeling and in vivo evaluation

M Nasr, IT Ibrahim, KM Attallah - Journal of Drug Delivery Science and …, 2024 - Elsevier
Lung cancer is a type of cancer which is characterized by high incidence and elevated
mortality rate. In an attempt to counteract the carcinogens' load and prevent the development …

[HTML][HTML] Spray-dried inhalable powder formulations of gentamicin designed for pneumonic plague therapy in a mouse model

M Zhu, D Zhang, L Zhang, L Zhao, L Xu, B Wang… - Pharmaceutics, 2022 - mdpi.com
Infection with Yersinia pestis (Y. pestis) may cause pneumonic plague, which is inevitably
fatal without treatment. Gentamicin (GM), an aminoglycoside antibiotic, is a drug commonly …