MicroRNA let-7 and viral infections: focus on mechanisms of action
A Letafati, S Najafi, M Mottahedi, M Karimzadeh… - Cellular & molecular …, 2022 - Springer
MicroRNAs (miRNAs) are fundamental post-transcriptional modulators of several critical
cellular processes, a number of which are involved in host defense mechanisms. In …
cellular processes, a number of which are involved in host defense mechanisms. In …
Broadly neutralizing antibodies to HIV and their role in vaccine design
DR Burton, L Hangartner - Annual review of immunology, 2016 - annualreviews.org
HIV employs multiple means to evade the humoral immune response, particularly the
elicitation of and recognition by broadly neutralizing antibodies (bnAbs). Such antibodies …
elicitation of and recognition by broadly neutralizing antibodies (bnAbs). Such antibodies …
Vaccination induces HIV broadly neutralizing antibody precursors in humans
Broadly neutralizing antibodies (bnAbs) can protect against HIV infection but have not been
induced by human vaccination. A key barrier to bnAb induction is vaccine priming of rare …
induced by human vaccination. A key barrier to bnAb induction is vaccine priming of rare …
Safety and antiviral activity of triple combination broadly neutralizing monoclonal antibody therapy against HIV-1: a phase 1 clinical trial
B Julg, KE Stephenson, K Wagh, SC Tan, R Zash… - Nature medicine, 2022 - nature.com
HIV-1 therapy with single or dual broadly neutralizing antibodies (bNAbs) has shown viral
escape, indicating that at least a triple bNAb therapy may be needed for robust suppression …
escape, indicating that at least a triple bNAb therapy may be needed for robust suppression …
Neutralization titer biomarker for antibody-mediated prevention of HIV-1 acquisition
PB Gilbert, Y Huang, AC deCamp, S Karuna… - Nature Medicine, 2022 - nature.com
Abstract The Antibody Mediated Prevention trials showed that the broadly neutralizing
antibody (bnAb) VRC01 prevented acquisition of human immunodeficiency virus-1 (HIV-1) …
antibody (bnAb) VRC01 prevented acquisition of human immunodeficiency virus-1 (HIV-1) …
Structure and immune recognition of trimeric pre-fusion HIV-1 Env
The human immunodeficiency virus type 1 (HIV-1) envelope (Env) spike, comprising three
gp120 and three gp41 subunits, is a conformational machine that facilitates HIV-1 entry by …
gp120 and three gp41 subunits, is a conformational machine that facilitates HIV-1 entry by …
Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus
Current human immunodeficiency virus-1 (HIV-1) vaccines elicit strain-specific neutralizing
antibodies. However, cross-reactive neutralizing antibodies arise in approximately 20% of …
antibodies. However, cross-reactive neutralizing antibodies arise in approximately 20% of …
Antibody responses to envelope glycoproteins in HIV-1 infection
DR Burton, JR Mascola - Nature immunology, 2015 - nature.com
Antibody responses to the HIV-1 envelope glycoproteins can be classified into three groups.
Binding but non-neutralizing responses are directed to epitopes that are expressed on …
Binding but non-neutralizing responses are directed to epitopes that are expressed on …
[HTML][HTML] Efficacy trial of a DNA/rAd5 HIV-1 preventive vaccine
SM Hammer, ME Sobieszczyk, H Janes… - … England Journal of …, 2013 - Mass Medical Soc
Background A safe and effective vaccine for the prevention of human immunodeficiency
virus type 1 (HIV-1) infection is a global priority. We tested the efficacy of a DNA prime …
virus type 1 (HIV-1) infection is a global priority. We tested the efficacy of a DNA prime …
Acute HIV-1 infection
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