The role of neurod genes in brain development, function, and disease

S Tutukova, V Tarabykin… - Frontiers in Molecular …, 2021 - frontiersin.org
Transcriptional regulation is essential for the correct functioning of cells during development
and in postnatal life. The basic Helix-loop-Helix (bHLH) superfamily of transcription factors is …

[HTML][HTML] bHLH transcription factors in neural development, disease, and reprogramming

DJ Dennis, S Han, C Schuurmans - Brain research, 2019 - Elsevier
The formation of functional neural circuits in the vertebrate central nervous system (CNS)
requires that appropriate numbers of the correct types of neuronal and glial cells are …

Origins, development, and compartmentation of the granule cells of the cerebellum

GG Consalez, D Goldowitz, F Casoni… - Frontiers in neural …, 2021 - frontiersin.org
Granule cells (GCs) are the most numerous cell type in the cerebellum and indeed, in the
brain: at least 99% of all cerebellar neurons are granule cells. In this review article, we first …

Development of the cerebellum: simple steps to make a 'little brain'

T Butts, MJ Green, RJT Wingate - Development, 2014 - journals.biologists.com
The cerebellum is a pre-eminent model for the study of neurogenesis and circuit assembly.
Increasing interest in the cerebellum as a participant in higher cognitive processes and as a …

The developmental origin of brain tumours: a cellular and molecular framework

R Azzarelli, BD Simons, A Philpott - Development, 2018 - journals.biologists.com
The development of the nervous system relies on the coordinated regulation of stem cell self-
renewal and differentiation. The discovery that brain tumours contain a subpopulation of …

[HTML][HTML] Cellular development and evolution of the mammalian cerebellum

M Sepp, K Leiss, F Murat, K Okonechnikov, P Joshi… - Nature, 2024 - nature.com
The expansion of the neocortex, a hallmark of mammalian evolution,, was accompanied by
an increase in cerebellar neuron numbers. However, little is known about the evolution of …

Evolutionary mechanisms that generate morphology and neural‐circuit diversity of the cerebellum

M Hibi, K Matsuda, M Takeuchi… - Development …, 2017 - Wiley Online Library
The cerebellum is derived from the dorsal part of the anterior‐most hindbrain. The vertebrate
cerebellum contains glutamatergic granule cells (GCs) and gamma‐aminobutyric acid …

The generation of granule cells during the development and evolution of the cerebellum

A Iulianella, RJ Wingate, CB Moens… - Developmental …, 2019 - Wiley Online Library
The cerebellum coordinates vestibular input into the hindbrain to control balance and
movement, and its anatomical complexity is increasingly viewed as a high‐throughput …

Effects of Neurod1 expression on mouse and human schwannoma cells

J Kersigo, L Gu, L Xu, N Pan, S Vijayakuma… - The …, 2021 - Wiley Online Library
Objectives The objective was to explore the effect of the proneuronal transcription factor
neurogenic differentiation 1 (Neurod1, ND1) on Schwann cells (SC) and schwannoma cell …

Transit amplifying progenitors in the cerebellum: similarities to and differences from transit amplifying cells in other brain regions and between species

S Miyashita, M Hoshino - Cells, 2022 - mdpi.com
Transit amplification of neural progenitors/precursors is widely used in the development of
the central nervous system and for tissue homeostasis. In most cases, stem cells, which are …