[HTML][HTML] Exerkines and long-term synaptic potentiation: Mechanisms of exercise-induced neuroplasticity
Physical exercise may improve cognitive function by modulating molecular and cellular
mechanisms within the brain. We propose that the facilitation of long-term synaptic …
mechanisms within the brain. We propose that the facilitation of long-term synaptic …
Cortical and striatal circuits in Huntington's disease
S Blumenstock, I Dudanova - Frontiers in neuroscience, 2020 - frontiersin.org
Huntington's disease (HD) is a hereditary neurodegenerative disorder that typically
manifests in midlife with motor, cognitive, and/or psychiatric symptoms. The disease is …
manifests in midlife with motor, cognitive, and/or psychiatric symptoms. The disease is …
Alterations in synaptic function and plasticity in Huntington disease
AI Smith‐Dijak, MD Sepers… - Journal of …, 2019 - Wiley Online Library
Huntington disease (HD) is an inherited neurodegenerative disorder caused by an
expansion of the CAG repeat region in the first exon of the huntingtin gene …
expansion of the CAG repeat region in the first exon of the huntingtin gene …
Dopamine imbalance in Huntington's disease: a mechanism for the lack of behavioral flexibility
Dopamine (DA) plays an essential role in the control of coordinated movements. Alterations
in DA balance in the striatum lead to pathological conditions such as Parkinson's and …
in DA balance in the striatum lead to pathological conditions such as Parkinson's and …
The role of dopamine in Huntington's disease
Alterations in dopamine (DA) neurotransmission in Parkinson's disease are well known and
widely studied. Much less is known about DA changes that accompany and underlie some …
widely studied. Much less is known about DA changes that accompany and underlie some …
Modulation of the glutamatergic transmission by Dopamine: a focus on Parkinson, Huntington and Addiction diseases
Dopamine (DA) plays a major role in motor and cognitive functions as well as in reward
processing by regulating glutamatergic inputs. In particular in the striatum the release of DA …
processing by regulating glutamatergic inputs. In particular in the striatum the release of DA …
Inactivation of adenosine A2A receptors reverses working memory deficits at early stages of Huntington's disease models
W Li, HB Silva, J Real, YM Wang, D Rial, P Li… - Neurobiology of …, 2015 - Elsevier
Cognitive impairments in Huntington's disease (HD) are attributed to a dysfunction of the
cortico-striatal pathway and significantly affect the quality of life of the patients, but this has …
cortico-striatal pathway and significantly affect the quality of life of the patients, but this has …
Dysfunctional striatal dopamine signaling in Huntington's disease
ET Koch, LA Raymond - Journal of neuroscience research, 2019 - Wiley Online Library
Dopamine signaling in the striatum is critical for a variety of behaviors including movement,
behavioral flexibility, response to reward and many forms of learning. Alterations to …
behavioral flexibility, response to reward and many forms of learning. Alterations to …
Role of cerebral cortex in the neuropathology of Huntington's disease
AM Estrada-Sánchez, GV Rebec - Frontiers in neural circuits, 2013 - frontiersin.org
An expansion of glutamine repeats in the N-terminal domain of the huntingtin protein leads
to Huntington's disease (HD), a neurodegenerative condition characterized by the presence …
to Huntington's disease (HD), a neurodegenerative condition characterized by the presence …
Synaptopathic mechanisms of neurodegeneration and dementia: Insights from Huntington's disease
Dementia encapsulates a set of symptoms that include loss of mental abilities such as
memory, problem solving or language, and reduces a person's ability to perform daily …
memory, problem solving or language, and reduces a person's ability to perform daily …