Physical exercise may improve cognitive function by modulating molecular and cellular
mechanisms within the brain. We propose that the facilitation of long-term synaptic …

Huntington's disease (HD) is a hereditary neurodegenerative disorder that typically
manifests in midlife with motor, cognitive, and/or psychiatric symptoms. The disease is …

Huntington disease (HD) is an inherited neurodegenerative disorder caused by an
expansion of the CAG repeat region in the first exon of the huntingtin gene …

Dopamine (DA) plays an essential role in the control of coordinated movements. Alterations
in DA balance in the striatum lead to pathological conditions such as Parkinson's and …

Alterations in dopamine (DA) neurotransmission in Parkinson's disease are well known and
widely studied. Much less is known about DA changes that accompany and underlie some …

Dopamine (DA) plays a major role in motor and cognitive functions as well as in reward
processing by regulating glutamatergic inputs. In particular in the striatum the release of DA …

Cognitive impairments in Huntington's disease (HD) are attributed to a dysfunction of the
cortico-striatal pathway and significantly affect the quality of life of the patients, but this has …

Dopamine signaling in the striatum is critical for a variety of behaviors including movement,
behavioral flexibility, response to reward and many forms of learning. Alterations to …

An expansion of glutamine repeats in the N-terminal domain of the huntingtin protein leads
to Huntington's disease (HD), a neurodegenerative condition characterized by the presence …

Dementia encapsulates a set of symptoms that include loss of mental abilities such as
memory, problem solving or language, and reduces a person's ability to perform daily …