Transthyretin (TTR) is one of the many proteins that are known to misfold and aggregate (ie,
undergo amyloidogenesis) in vivo. The process of TTR amyloidogenesis causes nervous …

Progression of brain ageing is influenced by a complex interaction of genetic and
environmental factors. Analysis of genetically modified animals with uniform genetic …

Biomarkers are the measurable changes associated with a physiological or
pathophysiological process. Unlike blood, urine is not subject to homeostatic mechanisms …

Transthyretin is a highly conserved homotetrameric protein, mainly synthetized by the liver
and the choroid plexus of brain. The carrier role of TTR is well-known; however, many other …

Peripheral neuropathy is a common complication of many of the systemic amyloidoses.
Although the cause of neuropathy is not entirely clear, it is likely related to amyloid …

Genetic, environmental, and aging-related insults can promote the misfolding and
subsequent aggregation of secreted proteins implicated in the pathogenesis of numerous …

Tissue-specific overexpression of the human systemic amyloid precursor transthyretin (TTR)
ameliorates Alzheimer's disease (AD) phenotypes in APP23 mice. TTR–β-amyloid (Aβ) …

Alzheimer's disease is associated with the deposition of the amyloid-β peptide (Aβ) into
extracellular senile plaques in the brain. In vitro and in vivo observations have indicated that …

The extracellular protein, transthyretin is responsible for the transport of thyroxin and retinol
binding protein complex to the various parts of the body. In addition to this transport function …

Background Alzheimer's disease (AD) is the leading cause of dementia affecting greater
than 26 million people worldwide. Although cerebrospinal fluid (CSF) levels of Aβ 42, tau …