Recent applications of hydantoin and thiohydantoin in medicinal chemistry
SH Cho, SH Kim, D Shin - European journal of medicinal chemistry, 2019 - Elsevier
Abstract Hydantoin, imidazolidine-2, 4-dione, is a non-aromatic five-membered heterocycle,
which is considered a valuable, privileged scaffold in medicinal chemistry. The importance …
which is considered a valuable, privileged scaffold in medicinal chemistry. The importance …
Voltage gated sodium channel inhibitors as anticonvulsant drugs: A systematic review on recent developments and structure activity relationship studies
Voltage-gated sodium channel blockers are one of the vital targets for the management of
several central nervous system diseases, including epilepsy, chronic pain, psychiatric …
several central nervous system diseases, including epilepsy, chronic pain, psychiatric …
[HTML][HTML] Quercetin, a natural flavonoid interacts with DNA, arrests cell cycle and causes tumor regression by activating mitochondrial pathway of apoptosis
Naturally occurring compounds are considered as attractive candidates for cancer treatment
and prevention. Quercetin and ellagic acid are naturally occurring flavonoids abundantly …
and prevention. Quercetin and ellagic acid are naturally occurring flavonoids abundantly …
[HTML][HTML] An inhibitor of nonhomologous end-joining abrogates double-strand break repair and impedes cancer progression
DNA Ligase IV is responsible for sealing of double-strand breaks (DSBs) during
nonhomologous end-joining (NHEJ). Inhibiting Ligase IV could result in amassing of DSBs …
nonhomologous end-joining (NHEJ). Inhibiting Ligase IV could result in amassing of DSBs …
Homology and enzymatic requirements of microhomology-dependent alternative end joining
Nonhomologous DNA end joining (NHEJ) is one of the major double-strand break (DSB)
repair pathways in higher eukaryotes. Recently, it has been shown that alternative NHEJ (A …
repair pathways in higher eukaryotes. Recently, it has been shown that alternative NHEJ (A …
Aqueous extract of Moringa oleifera exhibit potential anticancer activity and can be used as a possible cancer therapeutic agent: a study involving in vitro and in vivo …
D Barhoi, P Upadhaya, SN Barbhuiya… - Journal of the …, 2021 - Taylor & Francis
Objectives New cases of cancers are increasing at an alarming rate globally. It has been
hypothesized that modern cancer treatment is associated with lots of side effects and thus …
hypothesized that modern cancer treatment is associated with lots of side effects and thus …
Blockade of STAT3 signaling alleviates the progression of acute kidney injury to chronic kidney disease through antiapoptosis
JY Park, KD Yoo, E Bae, KH Kim… - American Journal …, 2022 - journals.physiology.org
Signal transducer and activator of transcription 3 (STAT3) is a pivotal mediator of IL-6-type
cytokine signaling. However, the roles of its full-length and truncated isoforms in acute …
cytokine signaling. However, the roles of its full-length and truncated isoforms in acute …
Synthesis and tumor inhibitory activity of novel coumarin analogs targeting angiogenesis and apoptosis
A sequence of coumarin analogs 5a–j was obtained by multi step synthesis from hydroxy
benzophenones (1a–j). The in vitro antiproliferative effect of the title compounds was tested …
benzophenones (1a–j). The in vitro antiproliferative effect of the title compounds was tested …
Extracts of strawberry fruits induce intrinsic pathway of apoptosis in breast cancer cells and inhibits tumor progression in mice
Background The consumption of berry fruits, including strawberries, has been suggested to
have beneficial effects against oxidative stress mediated diseases. Berries contain multiple …
have beneficial effects against oxidative stress mediated diseases. Berries contain multiple …
Synthesis and biological evaluation of novel 2-aralkyl-5-substituted-6-(4′-fluorophenyl)-imidazo [2, 1-b][1, 3, 4] thiadiazole derivatives as potent anticancer agents
Levamisole, the imidazo [2, 1-b] thiazole derivative has been reported as a potential
antitumor agent. In the present study, we synthesized, characterized and evaluated …
antitumor agent. In the present study, we synthesized, characterized and evaluated …