Cardiovascular and metabolic diseases (CVMD) are the leading causes of death worldwide,
underscoring the urgent necessity to develop new pharmacotherapies. Berberine (BBR) is …

P-glycoprotein (P-gp) is crucial in the active transport of various substrates with diverse
structures out of cells, resulting in poor intestinal permeation and limited bioavailability …

Berberine, a benzylisoquinoline alkaloid, occurs as an active constituent in numerous
medicinal plants and has an array of pharmacological properties. It has been used in …

Cancer arises in the context of an in vivo tumor microenvironment. This microenvironment is
both a cause and consequence of tumorigenesis. Tumor and host cells co-evolve …

Berberine (BBR) is an isoquinoline plant alkaloid endowed with several pharmacological
activities, including anti-microbial, glucose-and cholesterol-lowering, anti-tumoral and …

The biggest challenge associated with cancer chemotherapy is the development of cross
multi-drug resistance to almost all anti-cancer agents upon chronic treatment. The major …

Prediction of P-glycoprotein substrate specificity (S PGP) can be viewed as a constituent part
of a compound's “pharmaceutical profiling” in drug design. This task is difficult to achieve …

We aimed to develop a berberine formulation to enhance the intestinal absorption and
plasma concentrations of berberine through the inhibition of P-glycoprotein (P-gp)-mediated …

Cancer is the leading cause of death and one of the greatest barriers to increased life
expectancy worldwide. Currently, chemotherapy with synthetic drugs remains one of the …

Background Fuzi, which is the processed lateral roots of Aconitum carmichaeli
Debx.(Ranunculaceae), is a traditional herbal medicine that is well known for its excellent …