[HTML][HTML] Hepatocellular carcinoma
Liver cancer remains a global health challenge, with an estimated incidence of> 1 million
cases by 2025. Hepatocellular carcinoma (HCC) is the most common form of liver cancer …
cases by 2025. Hepatocellular carcinoma (HCC) is the most common form of liver cancer …
Advances in molecular classification and precision oncology in hepatocellular carcinoma
S Rebouissou, JC Nault - Journal of hepatology, 2020 - Elsevier
Hepatocellular carcinoma (HCC) arises from hepatocytes through the sequential
accumulation of multiple genomic and epigenomic alterations resulting from Darwinian …
accumulation of multiple genomic and epigenomic alterations resulting from Darwinian …
Mechanisms underlying the activation of TERT transcription and telomerase activity in human cancer: old actors and new players
X Yuan, C Larsson, D Xu - Oncogene, 2019 - nature.com
Long-lived species Homo sapiens have evolved robust protection mechanisms against
cancer by repressing telomerase and maintaining short telomeres, thereby delaying the …
cancer by repressing telomerase and maintaining short telomeres, thereby delaying the …
Pan-cancer analysis of whole genomes
Nature, 2020 - nature.com
Cancer is driven by genetic change, and the advent of massively parallel sequencing has
enabled systematic documentation of this variation at the whole-genome scale,–. Here we …
enabled systematic documentation of this variation at the whole-genome scale,–. Here we …
Regulation of human telomerase in homeostasis and disease
CM Roake, SE Artandi - Nature reviews Molecular cell biology, 2020 - nature.com
Telomerase is a ribonucleoprotein complex, the catalytic core of which includes the
telomerase reverse transcriptase (TERT) and the non-coding human telomerase RNA (hTR) …
telomerase reverse transcriptase (TERT) and the non-coding human telomerase RNA (hTR) …
Mechanisms of HBV-induced hepatocellular carcinoma
M Levrero, J Zucman-Rossi - Journal of hepatology, 2016 - Elsevier
Hepatitis B virus (HBV) contributes to hepatocellular carcinoma (HCC) development through
direct and indirect mechanisms. HBV DNA integration into the host genome occurs at early …
direct and indirect mechanisms. HBV DNA integration into the host genome occurs at early …
Genetic landscape and biomarkers of hepatocellular carcinoma
Hepatocellular carcinoma (HCC) has emerged as a major cause of cancer-related death. Its
mortality has increased in Western populations, with a minority of patients diagnosed at …
mortality has increased in Western populations, with a minority of patients diagnosed at …
HBV DNA integration: molecular mechanisms and clinical implications
Chronic infection with the Hepatitis B Virus (HBV) is a major cause of liver-related morbidity
and mortality. One peculiar observation in cells infected with HBV (or with closely‑related …
and mortality. One peculiar observation in cells infected with HBV (or with closely‑related …
Recurrent AAV2-related insertional mutagenesis in human hepatocellular carcinomas
JC Nault, S Datta, S Imbeaud, A Franconi, M Mallet… - Nature …, 2015 - nature.com
Hepatocellular carcinomas (HCCs) are liver tumors related to various etiologies, including
alcohol intake and infection with hepatitis B (HBV) or C (HCV) virus. Additional risk factors …
alcohol intake and infection with hepatitis B (HBV) or C (HCV) virus. Additional risk factors …
High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions
JC Nault, M Mallet, C Pilati, J Calderaro… - Nature …, 2013 - nature.com
Somatic mutations activating telomerase reverse-trancriptase promoter were recently
identified in several tumour types. Here we identify frequent similar mutations in human …
identified in several tumour types. Here we identify frequent similar mutations in human …