Isoxazole/Isoxazoline skeleton in the structural modification of natural products: a review
X Wang, Q Hu, H Tang, X Pan - Pharmaceuticals, 2023 - mdpi.com
Isoxazoles and isoxazolines are five-membered heterocyclic molecules containing nitrogen
and oxygen. Isoxazole and isoxazoline are the most popular heterocyclic compounds for …
and oxygen. Isoxazole and isoxazoline are the most popular heterocyclic compounds for …
The potency of heterocyclic curcumin analogues: An evidence-based review
Curcumin, a potent phytochemical, has been a significant lead compound and has been
extensively investigated for its multiple bioactivities. Owing to its natural origin, non-toxic …
extensively investigated for its multiple bioactivities. Owing to its natural origin, non-toxic …
Synthesis, biological evaluation and molecular docking of novel pyrazole derivatives as potent carbonic anhydrase and acetylcholinesterase inhibitors
A series of substituted pyrazole compounds (1–8 and 9a, b) were synthesized and their
structure was characterized by IR, NMR, and Mass analysis. These obtained novel pyrazole …
structure was characterized by IR, NMR, and Mass analysis. These obtained novel pyrazole …
Prodrug polymeric nanoconjugates encapsulating gold nanoparticles for enhanced X‐Ray radiation therapy in breast cancer
An optimal radiosensitizer with improved tumor retention has an important effect on tumor
radiation therapy. Herein, gold nanoparticles (Au NPs) and drug‐containing, mPEG …
radiation therapy. Herein, gold nanoparticles (Au NPs) and drug‐containing, mPEG …
[HTML][HTML] Complete ablation of tumors using synchronous chemoradiation with bimetallic theranostic nanoparticles
Synchronous chemotherapy and radiotherapy, termed chemoradiation therapy, is now an
important standard regime for synergistic cancer treatment. For such treatment …
important standard regime for synergistic cancer treatment. For such treatment …
Sulfonamides incorporating ketene N,S‐acetal bioisosteres as potent carbonic anhydrase and acetylcholinesterase inhibitors
In this study, 15 novel compounds in a series of sulfonamide‐based ketenes (7a–o) were
synthesized and characterized using Fourier‐transform infrared spectroscopy, nuclear …
synthesized and characterized using Fourier‐transform infrared spectroscopy, nuclear …
Pyrazole [3, 4-d] pyridazine derivatives: Molecular docking and explore of acetylcholinesterase and carbonic anhydrase enzymes inhibitors as anticholinergics …
Recently, the pyridazine nucleus has been widely studied in the field of particular and new
medicinal factors as drugs acting on the cardiovascular system. Additionally, a number of …
medicinal factors as drugs acting on the cardiovascular system. Additionally, a number of …
Curcumin nanoparticles: physicochemical fabrication, characterization, antioxidant, enzyme inhibition, molecular docking and simulation studies
Curcumin is an extensively studied natural compound due to its extensive biological
applications. However, there are some drawbacks linked to this compound such as poor …
applications. However, there are some drawbacks linked to this compound such as poor …
New acetamide-sulfonamide-containing scaffolds: antiurease activity screening, structure-activity relationship, kinetics mechanism, molecular docking, and md …
The development of novel scaffolds that can increase the effectiveness, safety, and
convenience of medication therapy using drug conjugates is a promising strategy. As a …
convenience of medication therapy using drug conjugates is a promising strategy. As a …
Phytochemicals as modulators of long non-coding RNAs and inhibitors of cancer-related carbonic anhydrases
T Saghafi, RA Taheri, S Parkkila… - International Journal of …, 2019 - mdpi.com
Long non-coding RNAs (lncRNAs) are classified as a group of transcripts which regulate
various biological processes, such as RNA processing, epigenetic control, and signaling …
various biological processes, such as RNA processing, epigenetic control, and signaling …