Viperin immunity evolved across the tree of life through serial innovations on a conserved scaffold
H Shomar, H Georjon, Y Feng, B Olympio… - Nature Ecology & …, 2024 - nature.com
Evolutionary arms races between cells and viruses drive the rapid diversification of antiviral
genes in diverse life forms. Recent discoveries have revealed the existence of immune …
genes in diverse life forms. Recent discoveries have revealed the existence of immune …
RAPIDASH: Tag-free enrichment of ribosome-associated proteins reveals composition dynamics in embryonic tissue, cancer cells, and macrophages
Ribosomes are emerging as direct regulators of gene expression, with ribosome-associated
proteins (RAPs) allowing ribosomes to modulate translation. Nevertheless, a lack of …
proteins (RAPs) allowing ribosomes to modulate translation. Nevertheless, a lack of …
[HTML][HTML] ANGPTL4-mediated microglial lipid droplet accumulation: Bridging Alzheimer's disease and obesity
N Li, X Wang, R Lin, F Yang, HC Chang, X Gu… - Neurobiology of …, 2024 - Elsevier
Increasing evidence suggests that metabolic disorders such as obesity are implicated in the
development of Alzheimer's disease (AD). The pathological buildup of lipids in microglia is …
development of Alzheimer's disease (AD). The pathological buildup of lipids in microglia is …
Flaviviruses manipulate mitochondrial processes to evade the innate immune response
RM Boytz, K Keita, JB Pawlak, M Laurent-Rolle - npj Viruses, 2024 - nature.com
Mitochondria are essential eukaryotic organelles that regulate a range of cellular processes,
from metabolism to calcium homeostasis and programmed cell death. They serve as …
from metabolism to calcium homeostasis and programmed cell death. They serve as …
[HTML][HTML] Transcriptomic signatures of Zika virus infection in patients and a cell culture model
G Berglund, CD Lennon, P Badu, JA Berglund… - Microorganisms, 2024 - mdpi.com
Zika virus (ZIKV), a re-emerging flavivirus, is associated with devasting developmental and
neurological disease outcomes particularly in infants infected in utero. Towards …
neurological disease outcomes particularly in infants infected in utero. Towards …
Microglial CMPK2 promotes neuroinflammation and brain injury after ischemic stroke
X Guan, S Zhu, J Song, K Liu, M Liu, L Xie, Y Wang… - Cell Reports …, 2024 - cell.com
Neuroinflammation plays a significant role in ischemic injury, which can be promoted by
oxidized mitochondrial DNA (Ox-mtDNA). Cytidine/uridine monophosphate kinase 2 …
oxidized mitochondrial DNA (Ox-mtDNA). Cytidine/uridine monophosphate kinase 2 …
Harnessing defective interfering particles and lipid nanoparticles for effective delivery of an anti-dengue virus RNA therapy
Currently, no approved antiviral drugs target dengue virus (DENV) infection, leaving
treatment reliant on supportive care. DENV vaccine efficacy varies depending on the …
treatment reliant on supportive care. DENV vaccine efficacy varies depending on the …
[HTML][HTML] RAPIDASH: A tag-free enrichment of ribosome-associated proteins reveals compositional dynamics in embryonic tissues and stimulated macrophages
Ribosomes are emerging as direct regulators of gene expression, with ribosome-associated
proteins (RAPs) allowing ribosomes to modulate translational control. However, a lack of …
proteins (RAPs) allowing ribosomes to modulate translational control. However, a lack of …
UMP‐CMP kinase 2 inhibits ZIKV replication through activation of type I IFN signaling pathway
Y Zhu, Q Tan, Y Shi, Q Li, S Li, W Wen… - Journal of Medical …, 2024 - Wiley Online Library
Cytidine/uridine monophosphate kinase 2 (UMP‐CMP kinase 2, CMPK2) has been reported
as an antiviral interferon‐stimulated gene (ISG). We previously observed that the expression …
as an antiviral interferon‐stimulated gene (ISG). We previously observed that the expression …
Zika virus infection in a cell culture model reflects the transcriptomic signatures in patients
G Berglund, CD Lennon, P Badu, JA Berglund… - …, 2024 - pmc.ncbi.nlm.nih.gov
Zika virus (ZIKV), a re-emerging flavivirus, is associated with devasting developmental and
neurological disease outcomes particularly in infants infected in utero. Towards …
neurological disease outcomes particularly in infants infected in utero. Towards …