Shear stress-induced activation of von Willebrand factor and cardiovascular pathology

S Okhota, I Melnikov, Y Avtaeva, S Kozlov… - International Journal of …, 2020 - mdpi.com
The von Willebrand factor (vWF) is a plasma protein that mediates platelet adhesion and
leukocyte recruitment to vascular injury sites and carries coagulation factor VIII, a building …

Prognostic value of plasma von Willebrand factor levels in major adverse cardiovascular events: a systematic review and meta-analysis

M Fan, X Wang, X Peng, S Feng, J Zhao, L Liao… - BMC Cardiovascular …, 2020 - Springer
Background Prediction of major adverse cardiovascular events (MACEs) may offer great
benefits for patients with coronary artery disease (CAD). Von Willebrand factor (vWF) is …

Modular 3D in vitro artery-mimicking multichannel system for recapitulating vascular stenosis and inflammation

M Cho, JK Park - Micromachines, 2021 - mdpi.com
Inflammation and the immune response in atherosclerosis are complex processes involving
local hemodynamics, the interaction of dysfunctional cells, and various pathological …

[HTML][HTML] Osteoprotegerin modulates platelet adhesion to von Willebrand factor during release from endothelial cells

N Wohner, S Sebastian, V Muczynski… - Journal of Thrombosis …, 2022 - Elsevier
Abstract Background Platelet‐binding Von Willebrand Factor (VWF) strings assemble upon
stimulated secretion from endothelial cells. Objectives To investigate the efficiency of platelet …

Plasma levels of von Willebrand factor in type 2 diabetes patients with and without cardiovascular diseases: A meta‐analysis

X Peng, X Wang, M Fan, J Zhao… - … Research and Reviews, 2020 - Wiley Online Library
Chronic vascular complications are the major causes of death and disability of type 2
diabetes mellitus (T2DM) patients. von Willebrand factor (vWF) is involved in pathogenesis …

Glycosylation changes of vWF in circulating extracellular vesicles to predict depression

N Yamada, K Tominaga, N Tominaga, A Kobayashi… - Scientific Reports, 2024 - nature.com
The clinical diagnosis of major depressive disorder (MDD) still depends on subjective
information in terms of various symptoms regarding mood. Detecting the characterization of …

[HTML][HTML] GATA3-induced vWF upregulation in the lung adenocarcinoma vasculature

Y Xu, S Pan, J Liu, F Dong, Z Cheng, J Zhang, R Qi… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Lung adenocarcinoma (LAC) is the leading cause of cancer-related death worldwide.
Aberrant expression of genes expressed preferentially in the lung tumor vasculature may …

Cadmium, von Willebrand factor and vascular aging

X Wang, MN Starodubtseva, CM Kapron, J Liu - npj Aging, 2023 - nature.com
Vascular aging is a major contributing factor to cardiovascular disease. The aged blood
vessels, characterized by vascular wall thickening and stiffening, are instigated by …

Role of von Willebrand factor in the angiogenesis of lung adenocarcinoma

X Li, Z Lu - Oncology Letters, 2022 - spandidos-publications.com
Lung adenocarcinoma (LUAD) has a high morbidity and mortality rate worldwide, and its
growth and metastasis require angiogenesis. The density of microvessels in LUAD is …

Targeting Tumor Endothelial Cells by EGCG Using Specific Liposome Delivery System Inhibits Vascular Inflammation and Thrombosis

Z Jia, N Maishi, H Takekawa, AY Matsuda… - Cancer …, 2024 - Wiley Online Library
Background Inflammation is one of the hallmarks of cancer and is associated with tumor
growth. Tumor endothelial cells (TECs) demonstrate inflamed phenotypes. Endothelial …