Various concentration gradient generation methods based on microfluidic systems are
summarized in this paper. The review covers typical structural characteristics, gradient …

Microfluidic spatial and temporal gradient generators have played an important role in many
biological assays such as in the analysis of wound healing, inflammation, and cancer …

Spatiotemporal manipulation of extracellular chemical environments with simultaneous
monitoring of cellular responses plays an essential role in exploring fundamental biological …

Accurate and fast control of fluid flow velocity and mixing is an essential technique for in vitro
cell or microbial culture. Here, we propose a cross microchannel structure based on …

One major challenge in current brain research is generating an integrative understanding of
the brain's functions and disorders from its multiscale neuronal architectures and …

Static in vitro cell culture studies cannot capture the dynamic concentration profiles of drugs,
nutrients, and other factors that cells experience in physiological systems. This limits the …

Microfluidics is an enabling technology for both cell biology and chemical analysis. We
combine these attributes with a microfluidic device for on-line solid-phase extraction (SPE) …

Cellular analysis is driven by the analytical methodologies available. Microfluidic systems
that allow high throughput, single cell analysis, which used to be only a distant goal that …

A microfluidic diffusion diluter to create stable chemical gradients across an array of cell
cultures was demonstrated. The device enabled concentration based studies to be …

The generation of dynamic biochemical signals in a microfluidic control system is of
importance for the study of the interaction between biological cells and their niches …