The clinical manifestation of neurodegenerative diseases is initiated by the selective
alteration in the functionality of distinct neuronal populations. The pathology of many …

Background Activating transcription factor 6 (ATF6) is an endoplasmic reticulum (ER)-
localised protein and member of the leucine zipper family of transcription factors. Best …

With advances in genomic sequencing technology, the number of reported gene-disease
relationships has rapidly expanded. However, the evidence supporting these claims varies …

Background The retina, as part of the central nervous system (CNS) with limited capacity for
self-reparation and regeneration in mammals, is under cumulative environmental stress due …

The unfolded protein response (UPR) plays a central role in regulating endoplasmic
reticulum (ER) and global cellular physiology in response to pathologic ER stress. The UPR …

The endoplasmic reticulum (ER) is the largest intracellular organelle carrying out a broad
range of important cellular functions including protein biosynthesis, folding, and trafficking …

Pharmacologic arm-selective unfolded protein response (UPR) signaling pathway activation
is emerging as a promising strategy to ameliorate imbalances in endoplasmic reticulum (ER) …

Glaucoma is the leading cause of irreversible blindness worldwide, and the burden of the
disease continues to grow as the global population ages. Currently, the only treatment …

The identification of the genes underlying monogenic diseases has been of interest to
clinicians and scientists for many years. Using inherited retinal dystrophies as an example of …

Neuronal proteostasis is maintained by the dynamic integration of different processes that
regulate the synthesis, folding, quality control, and localization of proteins. The endoplasmic …