Heterocyclic crown ethers with potential biological and pharmacological properties: From synthesis to applications

F Ullah, TA Khan, J Iltaf, S Anwar, MFA Khan… - Applied Sciences, 2022 - mdpi.com
Cyclic organic compounds with several ether linkages in their structure are of much concern
in our daily life applications. Crown ethers (CEs) are generally heterocyclic and extremely …

Investigation of in vitro and in silico effects of some novel carbazole Schiff bases on human carbonic anhydrase isoforms I and II

Y Camadan, B Çiçek, Ş Adem, Ü Çalişir… - Journal of …, 2022 - Taylor & Francis
Abstract Carbonic anhydrases (CAs, EC4. 2.1. 1) are metalloenzymes that catalyse
reversible hydration reaction of carbon dioxide to bicarbonate and protons. In recent years …

[PDF][PDF] Effects of Cefan melon (Cucumis melo L.) seed extracts on human erythrocyte carbonic anhydrase I-II enzymes.

E Akkemik, A Aybek, I Felek - Applied Ecology & Environmental Research, 2019 - aloki.hu
Carbonic anhydrases (CAs, EC 4.2. 1.1) are an important metalloenzyme family that
catalyzes reversible CO2 hydration and HCO3-dehydration in organisms. CA inhibitors can …

Microwave assisted synthesis of benzo-azacrown ethers and in vitro inhibition studies on hCA I–II

A Sapmaz, Ü Çalışır, E Akkemik, B Çiçek - Russian Journal of General …, 2023 - Springer
In this study, macro-ringed benzo-aza-oxa-crown ethers were synthesized by a cyclization
reaction between 2, 2′-dithiodianiline and mono/di/tri/tetraethylene glycol …

Synthesis, characterizations of aryl-substituted dithiodibenzothioate derivatives, and investigating their anti-Alzheimer's properties

Ü Çalışır, Y Camadan, B Çiçek, E Akkemik… - Journal of …, 2023 - Taylor & Francis
The main objective of the present study was to synthesize potential inhibitor/activators of
AChE and hCA I-II enzymes, which are thought to be directly related to Alzheimer's disease …

ICP-OES AND LC-ESI-MS/MS ANALYSES, ENZYME INHIBITION AND DNA PROTECTION POTENTIAL OF PELARGONIUM QUERCETORUM AGNEW.

E Akkemik, M Fidan, M Balaban… - … Babes-Bolyai, Chemia, 2022 - search.ebscohost.com
Pelargonium quercetorum Agnew extract affects activities of acetylcholinesterase (AChE)
and carbonic anhydrase I-II enzymes (hCA I-II) was investigated under in vitro conditions …

Investigation of the Effects of 1, 2, 4‐Triazole and Thiazole Ring‐Containing Hybrid Molecules on Carbonic Anhydrase I and II

Y Camadan, E Akkemik, P Güller, Ş Ceylan… - …, 2024 - Wiley Online Library
Abstract Carbonic anhydrase (CA, EC 4.2. 1.1) is an enzyme that catalyzes the reversible
reaction of carbon dioxide to bicarbonate and a proton under physiological conditions …

Asetoguanamin taç eterlerin mikrodalga yöntemiyle sentezi ve karakterizasyonu

S Yardan - 2023 - acikerisim.balikesir.edu.tr
Taç eterler katyonlara olan ilgileri sebebiyle metal kompleksleşmesi amacıyla sık sık
kullanılmaktadır. Bu tür bileşikler yapısı gereği, hidrofobik dış kavite ve hidrofilik iç kavite …

Synthesis, α‐Glucosidase Inhibitory Activity, and Molecular Docking Studies of Tri (benzo)‐5‐azacrownophanes with a γ‐Piperidone Moiety

DT Nhung, NN Tram, PTT Tam, KA Alekseeva… - …, 2023 - Wiley Online Library
Multicomponent reactions (MCR) are power tools in modern organic synthesis. These
reactions have many advantages over single component reactions, including saving time …

Çuha Çiçeği (Oenothera biennis) ve Tatlı Badem (Prunus dulcis Mill) Yağlarının Anti-enzim Aktivitelerinin Araştırılması

E Akkemik - Avrupa Bilim ve Teknoloji Dergisi, 2020 - dergipark.org.tr
Çalışmamızda iki farklı enzim aktivitesi üzerine Çuha çiçeği (Oenothera biennis) ile tatlı
badem (Prunus dulcis Mill.) yağlarının etkileri ne olabilecek sorusu cevaplanmak istendi …