Membrane lipids interact with proteins in a variety of ways, ranging from providing a stable
membrane environment for proteins to being embedded in to detailed roles in complicated …

Polyphosphoinositides (PPIs) are essential phospholipids located in the cytoplasmic leaflet
of eukaryotic cell membranes. Despite contributing only a small fraction to the bulk of cellular …

Docosahexaenoic acid is an omega-3 fatty acid that is essential for neurological
development and function, and it is supplied to the brain and eyes predominantly from …

Solute carrier (SLCs) transporters mediate the transport of a broad range of solutes across
biological membranes. Dysregulation of SLCs has been associated with various …

Monoamine transporters (MATs) regulate neurotransmission via the reuptake of dopamine,
serotonin and norepinephrine from extra-neuronal regions and thus maintain …

Rapid flip-flop of phospholipids across the two leaflets of biological membranes is crucial for
many aspects of cellular life. The transport proteins that facilitate this process are classified …

Classically, phenotype is what is observed, and genotype is the genetic makeup. Statistical
studies aim to project phenotypic likelihoods of genotypic patterns. The traditional genotype …

Found in all domains of life, transporters belonging to the LeuT-fold class mediate the import
and exchange of hydrophilic and charged compounds such as amino acids, metals, and …

The high-affinity K+ transporter HAK5 from Arabidopsis (Arabidopsis thaliana) is essential
for K+ acquisition and plant growth at low micromolar K+ concentrations. Despite its …

Solute carriers form one of three major superfamilies of membrane transporters in humans,
and include uniporters, exchangers and symporters. Following several decades of …