Transforming growth factor-β (TGF-β) signaling regulates cell-specific programs involved in
embryonic development, wound-healing, and immune homeostasis. Yet, during tumor …

Recently, nucleic acid drugs have been considered as promising candidates in treatment of
various diseases, especially cancer. Because of developing resistance to conventional …

Background Esophageal squamous cell carcinoma (ESCC) is a deadly gastrointestinal
malignancy, and chemotherapy resistance is a key factor leading to its poor prognosis. M2 …

Abstract Objective Metaplastic breast cancer (MpBC) is an aggressive subtype of all breast
cancer. We aimed to investigate the clinicopathological features, treatments and prognoses …

Therapeutic and diagnostic progresses have significantly reduced the mortality rate among
cancer patients during the last decade. However, there is still a high rate of mortality among …

Bladder cancer is the second‐most common malignancy in the urogenital system and the
most common in men. However, our understanding of the driving mechanisms of bladder …

Simple Summary Metaplastic breast carcinoma (MBC) is a rare, heterogenous group of
aggressive triple-negative breast cancers with a characteristically poor prognosis and …

Resistance to cancer therapeutics represents a leading cause of mortality and is particularly
important in cancers, such as triple negative breast cancer, for which no targeted therapy is …

Abstract Triple Negative Breast Cancer (TNBC) is the most aggressive type of breast cancer
(BC). Despite advances in the clinical management of TNBC, recurrence-related mortality …

Breast cancer, a prominent cause of mortality among women, develops from abnormal
growth of breast tissue, thereby rendering it one of the most commonly detected cancers in …