Macroautophagy (hereafter called autophagy) is a highly conserved physiological process
that degrades over-abundant or damaged organelles, large protein aggregates and …

Lipid droplets are cytosolic fat storage organelles present in most eukaryotic cells. Long
regarded merely as inert fat reservoirs, they are now emerging as major regulators of …

Nonalcoholic steatohepatitis (NASH) is a progressive disorder with aberrant lipid
accumulation and subsequent inflammatory and profibrotic response. Therapeutic efforts at …

Degrading pathogenic proteins by degrader technologies such as PROTACs (proteolysis-
targeting chimeras) provides promising therapeutic strategies, but selective degradation of …

Cancer cells possess remarkable abilities to adapt to adverse environmental conditions.
Their survival during severe nutrient and oxidative stress depends on their capacity to …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Mammalian oocytes and early cleavage-stage embryos are critically dependent on their~
100,000 mitochondria to develop from ovulation to compacted morula stage. They rely …

Lipids are indispensable for energy storage, membrane structure and cell signalling.
However, dynamic changes in various categories of endogenous lipids in mammalian early …

Autophagy is an intracellular degradation system that breaks down damaged organelles or
damaged proteins using intracellular lysosomes. Recent studies have also revealed that …

Abstract Significance: p62/SQSTM1 is a multifunctional scaffolding protein involved in the
regulation of various signaling pathways as well as autophagy. In particular, p62/SQSTM1 …