[HTML][HTML] Cellular and functional heterogeneity of the airway epithelium

JD Davis, TP Wypych - Mucosal immunology, 2021 - Elsevier
The airway epithelium protects us from environmental insults, which we encounter with
every breath. Not only does it passively filter large particles, it also senses potential danger …

Emerging roles of airway epithelial cells in idiopathic pulmonary fibrosis

A Chakraborty, M Mastalerz, M Ansari, HB Schiller… - Cells, 2022 - mdpi.com
Idiopathic pulmonary fibrosis (IPF) is a fatal disease with incompletely understood aetiology
and limited treatment options. Traditionally, IPF was believed to be mainly caused by …

Mapping spatially resolved transcriptomes in human and mouse pulmonary fibrosis

L Franzén, M Olsson Lindvall, M Hühn, V Ptasinski… - Nature Genetics, 2024 - nature.com
Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with poor prognosis and
limited treatment options. Efforts to identify effective treatments are thwarted by limited …

Targeting histone deacetylases in idiopathic pulmonary fibrosis: a future therapeutic option

M Korfei, P Mahavadi, A Guenther - Cells, 2022 - mdpi.com
Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease with limited
therapeutic options, and there is a huge unmet need for new therapies. A growing body of …

Allergic airway recall responses require IL-9 from resident memory CD4+ T cells

BJ Ulrich, R Kharwadkar, M Chu, A Pajulas… - Science …, 2022 - science.org
Asthma is a chronic inflammatory lung disease with intermittent flares predominately
mediated through memory T cells. Yet, the identity of long-term memory cells that mediate …

Small airway reduction and fibrosis is an early pathologic feature of idiopathic pulmonary fibrosis

K Ikezoe, TL Hackett, S Peterson, D Prins… - American journal of …, 2021 - atsjournals.org
Rationale: To improve disease outcomes in idiopathic pulmonary fibrosis (IPF), it is essential
to understand its early pathophysiology so that it can be targeted therapeutically. Objectives …

Molecular pathways and role of epigenetics in the idiopathic pulmonary fibrosis

V Velagacherla, CH Mehta, Y Nayak, UY Nayak - Life Sciences, 2022 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease with unknown etiological factors
that can progress to other dangerous diseases like lung cancer. Environmental and genetic …

[HTML][HTML] Human organotypic airway and lung organoid cells of bronchiolar and alveolar differentiation are permissive to infection by influenza and SARS-CoV-2 …

CT Ekanger, F Zhou, D Bohan, ML Lotsberg… - Frontiers in cellular …, 2022 - frontiersin.org
The ongoing coronavirus disease 2019 (COVID-19) pandemic has led to the initiation of
unprecedented research efforts to understand the pathogenesis mediated by Severe Acute …

Senescence of alveolar epithelial progenitor cells: A critical driver of lung fibrosis

T Parimon, P Chen, BR Stripp, J Liang… - … of Physiology-Cell …, 2023 - journals.physiology.org
Pulmonary fibrosis comprises a range of chronic interstitial lung diseases (ILDs) that impose
a significant burden on patients and public health. Among these, idiopathic pulmonary …

The critical role of osteopontin (OPN) in fibrotic diseases

Z Tang, Z Xia, X Wang, Y Liu - Cytokine & Growth Factor Reviews, 2023 - Elsevier
Fibrosis is a pathological condition characterized by the excessive deposition of
extracellular matrix components in tissues and organs, leading to progressive architectural …