The causative agent of human tuberculosis, Mycobacterium tuberculosis complex (MTBC),
comprises seven phylogenetically distinct lineages associated with different geographical …

Highlights•Management of tuberculosis is complicated by high levels of drug resistance in
some regions of the world.•Increasingly, molecular diagnostics are being used for resistance …

Strain-specific genomic diversity in the Mycobacterium tuberculosis complex (MTBC) is an
important factor in pathogenesis that may affect virulence, transmissibility, host response …

Mycobacterium tuberculosis drug resistance (DR) challenges effective tuberculosis disease
control. Current molecular tests examine limited numbers of mutations, and although whole …

In order to provide a global overview of genotypic, epidemiologic, demographic,
phylogeographical, and drug resistance characteristics related to the prevailing tuberculosis …

Tuberculosis (TB) was once a major killer in Europe, but it is unclear how the strains and
patterns of infection at 'peak TB'relate to what we see today. Here we describe 14 genome …

This monograph is written for healthcare workers in any setting who are faced with the
complex care for patients with tuberculosis. Prevention, diagnosis and treatment of …

Due to its rapid spread and association with the numerous outbreaks, the global spread of
East Asian lineage of Mycobacterium tuberculosis strains presents a global concern …

Tuberculosis remains a major global health problem. Laboratory diagnostic methods that
allow effective, early detection of cases are central to management of tuberculosis in the …

Drug-resistant tuberculosis poses a persistent public health threat. The ReSeqTB platform is
a collaborative, curated knowledgebase, designed to standardize and aggregate global …