Natural products in licorice for the therapy of liver diseases: Progress and future opportunities

X Li, R Sun, R Liu - Pharmacological Research, 2019 - Elsevier
Liver diseases related complications represent a significant source of morbidity and mortality
worldwide, creating a substantial economic burden. Oxidative stress, excessive …

Botanicals and their bioactive phytochemicals for women's health

BM Dietz, A Hajirahimkhan, TL Dunlap, JL Bolton… - Pharmacological …, 2016 - Elsevier
Botanical dietary supplements are increasingly popular for women's health, particularly for
older women. The specific botanicals women take vary as a function of age. Younger …

Role of licochalcone A in potential pharmacological therapy: a review

MT Li, L Xie, HM Jiang, Q Huang, RS Tong… - Frontiers in …, 2022 - frontiersin.org
Licochalcone A (LA), a useful and valuable flavonoid, is isolated from Glycyrrhiza uralensis
Fisch. ex DC. and widely used clinically in traditional Chinese medicine. We systematically …

Nrf2 activation in chronic kidney disease: promises and pitfalls

AK Aranda-Rivera, A Cruz-Gregorio… - Antioxidants, 2022 - mdpi.com
The nuclear factor erythroid 2-related factor 2 (Nrf2) protects the cell against oxidative
damage. The Nrf2 system comprises a complex network that functions to ensure adequate …

Activation of Nrf2 signaling pathway by natural and synthetic chalcones: A therapeutic road map for oxidative stress

MC Egbujor, S Saha, B Buttari, E Profumo… - Expert review of clinical …, 2021 - Taylor & Francis
Introduction: Nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway plays a key
role in diverse gene expressions responsible for protection against oxidative stress and …

Identification and chemical standardization of licorice raw materials and dietary supplements using UHPLC-MS/MS

G Li, D Nikolic, RB Van Breemen - Journal of Agricultural and …, 2016 - ACS Publications
Defined as the roots and underground stems of principally three Glycyrrhiza species,
Glycyrrhiza glabra L., Glycyrrhiza uralensis Fish. ex DC., and Glycyrrhiza inflata Batalin …

Licochalcone A, a licorice flavonoid: Antioxidant, cytotoxic, genotoxic, and chemopreventive potential

KS de Freitas, IS Squarisi, NO Acesio… - Journal of Toxicology …, 2020 - Taylor & Francis
Licochalcone A (LicoA) is a flavonoid derived from Glycyrrhiza spp. plants. The present
study aimed to investigate the antioxidant, cytotoxic, genotoxic, and chemopreventive effects …

Licochalcone A activates Keap1-Nrf2 signaling to suppress arthritis via phosphorylation of p62 at serine 349

X Su, T Li, Z Liu, Q Huang, K Liao, R Ren, L Lu… - Free Radical Biology …, 2018 - Elsevier
Licochalcone A (LCA) is derived from glycyrrhizae radix with antimicrobial, antitumor and
anti-inflammatory activities. However, the anti-arthritic function of LCA and underlying …

Cytochrome P450 inhibition by three licorice species and fourteen licorice constituents

G Li, C Simmler, L Chen, D Nikolic, SN Chen… - European Journal of …, 2017 - Elsevier
The potential of licorice dietary supplements to interact with drug metabolism was evaluated
by testing extracts of three botanically identified licorice species (Glycyrrhiza glabra L …

Co-exposure to aristolochic acids I and II increases DNA adduct formation responsible for aristolochic acid I-mediated carcinogenicity in rats

F Bárta, A Dedíková, M Bebová, Š Dušková… - International journal of …, 2021 - mdpi.com
The plant extract aristolochic acid (AA), containing aristolochic acids I (AAI) and II (AAII) as
major components, causes aristolochic acid nephropathy (AAN) and Balkan endemic …