Heart failure (HF) has become increasingly common within the elderly population,
decreasing their survival and overall quality of life. In fact, despite the improvements in …

Oxidative stress is a common mediator in pathogenicity of established cardiovascular risk
factors. Furthermore, it likely mediates effects of emerging, less well-defined variables that …

The Na/K-ATPase (NKA), or Na pump, is a member of the P-type ATPase superfamily. In
addition to pumping ions across cell membrane, it is engaged in assembly of multiple …

Glutathione (GSH) is the most abundant antioxidant and a major detoxification agent in cells.
It is synthesized through two-enzyme reaction catalyzed by glutamate cysteine ligase and …

The third isotype of beta-adrenoreceptors (β3-AR) has recently come (back) into focus after
the observation of its expression in white and beige human adipocytes and its implication in …

The two branches of the autonomic nervous system (ANS), adrenergic and cholinergic, exert
a multitude of effects on the human myocardium thanks to the activation of distinct G protein …

Cardiac diseases, such as heart failure, remain leading causes of morbidity and mortality
worldwide, with myocardial infarction as the most common etiology. HF is characterized by β …

Nitric oxide (NO) is a powerful mediator with biological activities such as vasodilation and
prevention of vascular smooth muscle cell proliferation as well as functional regulation of …

Disturbed metabolism as a consequence of obesity and diabetes may cause cardiac
diseases (recently highlighted in the cardiovascular research spotlight issue on metabolic …

Reversible protein S-glutathiolation has emerged as an important mechanism of post-
translational modification. Under basal conditions several proteins remain adducted to …