Intravenous β‐lactam antibiotics remain a cornerstone in the management of bacterial
infections due to their broad spectrum of activity and excellent tolerability. β‐lactams are well …

Physiologic alterations seen in obesity commonly impact the pharmacokinetics (PK) and
pharmacodynamics (PD) of antibiotics and may result in suboptimal dosing in this …

Purpose Pseudomonas aeruginosa is a commonly isolated nosocomial pathogen for which
treatment options are often limited for multidrug-resistant isolates. In addition to newer …

Objective We investigated the pharmacokinetic (PK) and pharmacodynamic (PD)
parameters of linezolid in patients who had suffered cerebral hemorrhage after lateral …

Background: Nosocomial pneumonia (NP) is a frequent complication among patients with
intracerebral hemorrhage (ICH). However, there are currently no pharmacokinetic (PK) and …

The aim of this study was to investigate the pharmacokinetics (PK) of doripenem in healthy
Chinese subjects and evaluate the optimal dosage regimens of doripenem. A randomized …

Background: Dose adjustment is often required in patients with normal or enhanced renal
function. The aim of this study is to investigate the pharmacokinetic (PK) properties of …

Intravenous β-lactam antibiotics remain a cornerstone in the management of bacterial
infections due to their broad spectrum of activity and excellent tolerability. β-lactams are well …

В настоящее время в развитых странах ожирением страдают от 15 до 50% населения.
Пациенты с ожирением имеют более высокий риск возникновения инфекций, у них …

Objective: Patients with cerebral hemorrhage are often prone to intracranial infection, and
meropenem is recommended for treatment. But whether the widely used dosing regimen (1 …