Twelve regulated cell death programs have been described. We review in detail the basic
biology of nine including death receptor-mediated apoptosis, death receptor-mediated …

The principal tumour-suppressor protein, p53, accumulates in cells in response to DNA
damage, oncogene activation and other stresses. It acts as a nuclear transcription factor that …

Cell death was once viewed as unregulated. It is now clear that at least a portion of cell
death is a regulated cell suicide process. This type of death can exhibit multiple …

Even 30 years after its discovery, the tumor suppressor protein p53 is still somewhat of an
enigma. p53's intimate and multifaceted role in the cell cycle is mirrored in its equally …

The p53 tumor suppressor functions as a tetrameric transcription factor to regulate hundreds
of genes—many in a tissue-specific manner. Missense mutations in cancers in the p53 DNA …

Tetramer formation of p53 is essential for its tumor suppressor function. p53 not only acts as
a tumor suppressor protein by inducing cell cycle arrest and apoptosis in response to …

The unique chemistry of oxygen has been both a resource and threat for life on Earth for at
least the last 2.4 billion years. Reduction of oxygen to water allows extraction of more …

The emergence of mitochondria as critical regulators of cardiac myocyte survival and death
has revolutionized the field of cardiac biology. Indeed, it is now well recognized that …

During acute myocardial infarction and in the reperfused heart, loss of cardiomyocytes is
mostly caused by apoptosis and necrosis. As apoptosis was considered as the only form of …

Histone deacetylase (HDAC) inhibitors have been used to promote neuronal survival and
ameliorate neurological dysfunction in a host of neurodegenerative disease models. The …