Human small heat shock proteins are molecular chaperones that regulate fundamental
cellular processes in normal unstressed cells as well as in many cancer cells where they are …

Background Lung adenocarcinoma (LUAD) is the most common histologic subtype of lung
cancer and has a high risk of distant metastasis at every disease stage. We aimed to …

Puberty is a complex physiological event by which animals mature into an adult capable of
sexual reproduction. In order to enhance our understanding of the genes and regulatory …

Background Acute myeloid leukemia (AML) is initiated and maintained by a subset of self-
renewing leukemia stem cells (LSCs), which contribute to the progression, recurrence and …

Metabolic and cardiovascular diseases are highly prevalent and chronic conditions that are
closely linked by complex molecular and pathological changes. Such adverse effects often …

As a POU homeodomain transcription factor, POU4F2 has been implicated in regulating
tumorigenic processes in various cancers. However, the role of POU4F2 in colorectal cancer …

Phenotypic and functional changes in vascular smooth muscle cells (VSMCs) contribute
significantly to cardiovascular diseases (CVD) but factors driving early adverse vascular …

Aims Colon cancer poses a major threat to human health and a heavy burden on the
national economy. As a member of the SOX transcription factor family, SRY-box transcription …

Congenital heart defects contribute to embryonic or neonatal lethality but due to the
complexity of cardiac development, the molecular changes associated with such defects are …

Adult hearts respond to increased workload such as prolonged stress or injury, by
undergoing hypertrophic growth. During this process, the early adaptive responses are …