Sulfonyl fluorides as targets and substrates in the development of new synthetic methods

TSB Lou, MC Willis - Nature Reviews Chemistry, 2022 - nature.com
The advent of sulfur (vi)-fluoride exchange (SuFEx) processes as transformations with click-
like reactivity has invigorated research into electrophilic species featuring a sulfur–fluorine …

[HTML][HTML] Triazoles and their derivatives: Chemistry, synthesis, and therapeutic applications

MM Matin, P Matin, MR Rahman… - Frontiers in molecular …, 2022 - frontiersin.org
Among the nitrogen-containing heterocyclic compounds, triazoles emerge with superior
pharmacological applications. Structurally, there are two types of five-membered triazoles: 1 …

EnT-mediated N–S bond homolysis of a bifunctional reagent leading to aliphatic sulfonyl fluorides

JE Erchinger, R Hoogesteger, R Laskar… - Journal of the …, 2023 - ACS Publications
Sulfur (VI) fluoride exchange (SuFEx) gives rise to a plethora of high-valent sulfur linkages;
however, the availability of (aliphatic) sulfonyl fluoride manifolds lag behind, owing to the …

The growing applications of SuFEx click chemistry

AS Barrow, CJ Smedley, Q Zheng, S Li… - Chemical Society …, 2019 - pubs.rsc.org
SuFEx (Sulfur Fluoride Exchange) is a modular, next generation family of click reactions,
geared towards the rapid and reliable assembly of functional molecules. This review …

SuFExable polymers with helical structures derived from thionyl tetrafluoride

S Li, G Li, B Gao, SP Pujari, X Chen, H Kim, F Zhou… - Nature …, 2021 - nature.com
Sulfur (vi) fluoride exchange (SuFEx) is a category of click chemistry that enables covalent
linking of modular units through sulfur (vi) connective hubs. The efficiency of SuFEx and the …

Electrochemical Oxo‐Fluorosulfonylation of Alkynes under Air: Facile Access to β‐Keto Sulfonyl Fluorides

D Chen, X Nie, Q Feng, Y Zhang… - Angewandte Chemie …, 2021 - Wiley Online Library
Radical fluorosulfonylation is emerging as an appealing approach for the synthesis of
sulfonyl fluorides, which have widespread applications in many fields, in particular in the …

SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase

Q Zheng, JL Woehl, S Kitamura… - Proceedings of the …, 2019 - National Acad Sciences
Sulfur fluoride exchange (SuFEx) has emerged as the new generation of click chemistry. We
report here a SuFEx-enabled, agnostic approach for the discovery and optimization of …

Emerging building blocks for medicinal chemistry: recent synthetic advances

OO Grygorenko, DM Volochnyuk… - European Journal of …, 2021 - Wiley Online Library
Current medicinal chemistry relies heavily on the quality of building blocks, ie reagents used
to introduce chemical diversity into the target molecules. The last decade witnessed an …

Introducing A New Class of Sulfonyl Fluoride Hubs via Radical Chloro‐Fluorosulfonylation of Alkynes

X Nie, T Xu, Y Hong, H Zhang, C Mao… - Angewandte Chemie …, 2021 - Wiley Online Library
Sulfonyl fluorides have widespread applications in many important fields, including ligation
chemistry, chemical biology, and drug discovery. Therefore, new methods to increase the …

Linkage chemistry of S (VI) fluorides

D Zeng, WP Deng, X Jiang - Chemistry–A European Journal, 2023 - Wiley Online Library
Sulfur (VI)‐fluoride exchange linkage as a next generation of click chemistry was introduced
by Sharpless and coworkers in 2014. Distinguished from CuAAC, the SuFEx reaction …